, Volume 1, Issue 2, pp 157–162 | Cite as

The circadian clock in old Drosophila melanogaster

  • Christopher Driver


A growing body of evidence indicates that one of theage-associated changes in the central nervous systemthat affect most old people is the loss of functionof the circadian clock system. This loss results inimpaired timing and quality of sleep, with consequentcognitive and other behavior problems. Failure of theclock contributes to the difficulties encountered withAlzheimer's disease. It also results in adversechanges in the hormonal regulation of intermediarymetabolism, stress resistance and sexual function.Drosophila melanogaster is proposed as a modelorganism where this age-related change may be studiedmore readily. Circadian patterns are disrupted inDrosophila, with considerable differences betweenstrains. In addition a fusion gene product of a keygene involved in the clock (per), and GreenFluorescent Protein, shows a 50% fall with age.

ageing circadian activity patterns clock Drosophila fusion green fluorescent protein per 


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  1. Arking R, Buck S, Wells SA, and Pretzlaff R (1988) Metabolic rates in genetically based long lived strains of Drosophila. Exp Gerontol 23: 59–76PubMedGoogle Scholar
  2. Bargiello TA, Jackson FR and Young MW (1984) Restoration of circadian behavioral rhythms by gene transfer in Drosophila. Nature 312: 752–754PubMedGoogle Scholar
  3. Cai A and Wise PM (1996) Age-related changes in light induced Jun B and Jun D expression: effects of transplantation of fetal tissue containing the suprachiasmatic nucleus. J Biol Rhythms 11: 284–290PubMedGoogle Scholar
  4. Cai A, Scarborough K, Hinkle DA and Wise PM (1997) Fetal grafts containing suprachiasmatic nuclei restore the circadian rhythm of CRH and POMC mRNA in aging rats. Am J Physiol 273: R1764–R1770PubMedGoogle Scholar
  5. Copinschi G and Van Cauter E (1995) Effects of ageing on modulation of hormonal secretions by sleep and circadian rhythmicity. Horm Res 43: 20–24PubMedGoogle Scholar
  6. Donaldson C, Tarrier N and Burns A (1998) Determinants of carer stress in Alzheimer's disease. Int J Geriatr Psychiatr 13: 248–256Google Scholar
  7. Driver CJI and Cosopodiotis G (1978) The effect of a high fat diet on longevity of Drosophila melanogaster. Exp Gerontol 14: 95–100Google Scholar
  8. Driver CJI, Cosopodiotis G, Wallis R and Ettershank G (1986) Is a fat metabolite the major diet dependant accelerator of ageing? Exp Gerontol 21: 497–507PubMedGoogle Scholar
  9. Ewer J, Fritsch B, Hamblen-Coyle MJ, Roshbash M and Hall JC (1992) Expression of the period clock gene within different cell types in the brain of Drosophila adults and mosaic analysis of these cells influence on Circadian behavioral rhythms. J Neurosci 12: 3321–3349PubMedGoogle Scholar
  10. Gallo PV and Weinberg J (1981) Corticosterone rhythmicity in the rat: interactive effects of dietary restriction and schedule of feeding. J Nutr 111: 208–218PubMedGoogle Scholar
  11. Hofman MA and Swaab DF (1994) Alterations in the circadian rhythmicity of the vasopressin-producing neurons of the human suprachiasmatic nucleus (SCN) with age. Brain Res 651: 134–142PubMedGoogle Scholar
  12. Hurd MW, Zimmer KA, Lehman MN and Ralph MR (1995) Circadian locomotor rhythms in aged hamsters following suprachiasmatic transplants. Am J Physiol 269: R958–R968PubMedGoogle Scholar
  13. Kawakami F, Okamura H, Tamada Y, Maebayashi Y, Fukai K and Ibata Y (1997) Loss of Day-night differences in VIP mRNA levels in the suprachiasmatic nucleus of aged rats. Neurosci Lett 222: 99–102PubMedGoogle Scholar
  14. Krishnan B, Dryer SE and Hardin PE (1999) Circadian rhythms in olfactory responses of Drosophila melanogaster. Nature 400: 375–378PubMedGoogle Scholar
  15. Lolova IS, Davidoff MS and Yakimoff NA (1996) Vasopressin and Oxytocin-immunoreactive nerve cells in the aging rat hypothalamus. Acta Physiol Pharmacol Bulg 22: 7–16PubMedGoogle Scholar
  16. Mirmiran M, Swaab DF, Kok JH, Hofman MA, Witting W and Van Gool WA (1992) Circadian Rhythms and the suprachiasmatic nucleus in neonatal development, aging and Alzheimer's disease. Prog Brain Res 93: 151–162. Discussion 162–163PubMedGoogle Scholar
  17. Mocchegiani E, Paolucci P, Balsamo A, Cacciari E and Fabris N (1990) Influence of growth hormone on thymic endocrine activity in humans. Horm Res 33: 248–255PubMedGoogle Scholar
  18. Plautz JD, Kaneko M, Hall JC and Kay SA (1997) Independent Photoreceptive Circadian Clocks throughout Drosophila. Science 278: 1632–1635PubMedGoogle Scholar
  19. Roche JP, Talyn BC, and Dowse HB (1998) Courtship bout duration in per circadian period mutants in Drosophila melanogaster. Behav Genet 28: 391–394PubMedGoogle Scholar
  20. Rodin J, McAvay G and Timko C (1998) A longitudinal study of depressed mood and sleep disturbances in elderly adults. J Gerontol 43: P45–P53Google Scholar
  21. Rumble R and Morgan K (1992) Hypnotics, sleep and mortality in elderly people. J Am Geriatr Soc 40: 787–791PubMedGoogle Scholar
  22. Sakamoto K, Nagase T, Fukui H, Horikawa K, Okada T, Tanaka H, Sato K, Miyake Y, Ohara O, Kako K and Ishada N (1998) Multitissue circadian expression of rat period homologue (rPer2) mRNA is governed by the mammalian circadian clock, the suprachiasmatic nucleus in the brain. J Biol Chem 273: 27039–27042PubMedGoogle Scholar
  23. Satinoff E, Li H, Tcheng TK, Liu C, McArthur AJ, Medinic M and Gillette MU(1993) Do the suprachiasmatic nuclei oscillate in old rats as they do in young one? Am J Physiol 265: R1216–R1222PubMedGoogle Scholar
  24. Simpkins JW and Millard WJ (1987) Influence of age on neurotransmitter function. Endocrinol Metab Clin North Am 16: 893–917PubMedGoogle Scholar
  25. Tsai YF, Tai MY, Wang HJ and Lu KS (1990) Effects of long term dietary restriction on body temperature are modified with increasing age. Proc Natl Counc Repub China B 14: 217–222Google Scholar
  26. Walcott EC and Tate BA (1996) Entrainment of aged, dysrhythmic rats to a restricted feeding schedule. Physiol Behav 60: 1205–1258Google Scholar
  27. White W and Timberlake W (1999) Meal-engendered circadianensuing activity in rats. Physiol Behav 65: 625–642PubMedGoogle Scholar
  28. Wise PM, Cohen IR, Weiland NG and London ED (1988) Aging alters the circadian rhythm of glucose utilization in the suprachiasmatic nucleus. Proc Natl Acad Sci (USA) 85: 5305–5309PubMedGoogle Scholar
  29. Zhou JN, Hofman MA, Swaab DF (1995) VIP neurons in the human SCN in relation to sex, age, and Alzheimer's disease. Neurobiol Aging 16: 571–576PubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • Christopher Driver
    • 1
  1. 1.National Ageing Research InstituteUniversity ofMelbourneParkvilleAustralia (e-mail:

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