Biomedical Microdevices

, Volume 2, Issue 2, pp 131–144

Tissue Engineering at the Micro-Scale

  • Sangeeta N. Bhatia
  • Christopher S. Chen

Abstract

The possibility to replace damaged or diseased organs with artificial tissues engineered from a combination of living cells and biocompatible scaffolds is becoming a reality through multi-disciplinary efforts. A number of critical components within this effort are being facilitated by microfabrication and MEMS approaches, including research tools to elucidate mechanisms which control cellular behavior as well as development of methods to manufacture cellular scaffolds at ever higher resolutions. This article reviews recent advances in tissue engineering that have been facilitated by interaction with the microfabrication community. We highlight the potential opportunities for microfabrication to make to the development of mainstream medical therapies for tissue replacement.

Abbreviations

CAD

computer-aided design

ECM

extracellular matrix

PMMA

polymethyl methacrylate

PDMS

polydimethyl siloxane

PLA

polylactic acid

PLGA

polylactic (co-glycolic) acid

SFF

solid freeform fabrication

TEMP

tissue engineered medical product

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Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • Sangeeta N. Bhatia
    • 1
  • Christopher S. Chen
    • 2
  1. 1.Department of BioengineeringUniversity of CaliforniaSan Diego, La Jolla
  2. 2.Department of Biomedical EngineeringJohns Hopkins UniversityBaltimore

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