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Heart Failure Reviews

, Volume 6, Issue 1, pp 27–34 | Cite as

Electric Currents Applied During the Refractory Period Can Modulate Cardiac Contractility In Vitro and In Vivo

  • Daniel BurkhoffMD PhD
  • Itzik Shemer
  • Bella Felzen
  • Juichiro Shimizu
  • Yuval Mika
  • Marc Dickstein
  • David Prutchi
  • Nissim Darvish
  • Shlomo A. Ben-Haim
Article

Keywords

Public Health Electric Current Current Apply Refractory Period Cardiac Contractility 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    The effect of digoxin on mortality and morbidity in patients with heart failure. The Digitalis Investigation Group. N Engl J Med 2000;336:525–533.Google Scholar
  2. 2.
    Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. The SOLVD Investigators. N Engl J Med 2000;325:293–302.Google Scholar
  3. 3.
    Pitt B, Zannad F, Remme WJ, Cody R, Castaigne A, Palensky J, Wittes J. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999;341: 709–717Google Scholar
  4. 4.
    Packer M, Bristow MR, Cohn JN, Colucci WS, Fowler MB, Gilbert EM, Shusterman NH. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. U.S. Carvedilol Heart Failure Study Group. N Engl J Med 1996;334: 1349–1355.Google Scholar
  5. 5.
    Hjalmarson A, Goldstein S, Fagerberg B, Wedel H, Waagstein F, Kjekshus J, Wikstrand J, El Allaf D, Vitovic J, Aldershvile J, Halinen M, Dietz R, Neuhaus KL, Janosi A, Thorgeirsson G, Dunselman PH, Gullestad L, Kuch J, Herlitz J, Rickenbacher P, Ball S, Gottlieb S, Beedwania P. Effects of controlled-release metoprolol on total mortality, hospitalizations, and well-being in patients with heart failure: The Meto-Fig. 9. LV dP=dtmax and peak aortic Øow values as a function of time with CCM signal repeatedly applied for _20 minutes at a time over 2 hours. As shown, the inotropic effect is seen each time the signal is applied (bars). Cardiac Contratility Modulation by Electric Currents 33 prolol CR/XL Randomized Intervention Trial in congestive heart failure (MERIT-HF). MERIT-HF Study Group. JAMA 2000;283:1295–1302.Google Scholar
  6. 6.
    Effect of oral milrinone on mortality in severe chronic heart failure. The PROMISE Study Research Group. N Engl J Med 1991;325:1468–1475.Google Scholar
  7. 7.
    Packer M, Colucci WS, Sackner-Bernstein JD, Kiang CS, Goldscher DA, Freeman I, Kukin ML, Kinhal V, Udelson JE, Klapholz M, Gottlieb SS, Pearle D, Cody RJ, Gregory JJ, Kantrowitz NE, LeJemtel TH, Young ST, Lukas MA, Shusterman NH. Double-blind, placebo-controlled study of the effects of carvedilol in patients with moderate to severe heart failure. The PRECISE Trial. Prospective Randomized Evaluation of Carvedilol on Symptoms and Exercise. Circulation 1996;94:2799.Google Scholar
  8. 8.
    Burkhoff D, Oikawa RY, Sagawa K. Influence of pacing site on canine left ventricular contraction. Am J Physiol 1986;251 (HCP 20):H428-H435.Google Scholar
  9. 9.
    Kass DA, Chen CH, Curry C, Talbot M, Berger R, Fetics B, Nevo E. Improved left ventricular mechanics from acute VDD pacing in patients with dilated cardiomyopathy and ventricular conduction delay. Circulation 1999;99:1567–1573.Google Scholar
  10. 10.
    Auricchio A, Stellbrink C, Block M, Sack S, Vogt J, Bakker P, Klein H, Kramer A, Ding J, Salo R, Tockman B, Pochet T, Spinelli J. Effect of pacing chamber and atrioventricular delay on acute systolic function of paced patients with congestive heart failure. Circulation 1999;99:2993–3001.Google Scholar
  11. 11.
    Nelson GS, Curry CW, Wyman BT, Kramer A, Declerck J, Talbot M, Bouglas MR, Berger RD, McVeigh ER, Kass DA. Predictors of systolic augmentation from left ventricular preexcitation in patients with dilated cardiomyopathy and intraventricular conduction delay. Circulation 2000;101:2703–2709.Google Scholar
  12. 12.
    Gomez AM, Valdivia HH, Cheng H, Lederer MR, Santana LF, Cannell MB, McCune SA, Altschuld RA, Lederer WJ. Defective excitation±contraction coupling in experimental heart failure. Science 1997;276:800–806.Google Scholar
  13. 13.
    Hasenfuss G, Reinecke H, Studer R, Meyer M, Pieske B, Holtz J, Holubarsch C, Posival H, Just H, Drexler H. Relation between myocardial function and expression of sarcoplasmic reticulum Ca2 +-ATPase in failing and nonfailing human myocardium. Circ Res 1994;75:434–442.Google Scholar
  14. 14.
    Wood EH, Heppner RL, Weidmann S. Inotropic effects of electric currents: 1. Positive and negative effects of constant electric currents or current pulses applied during cardiac action potential. Circ Res 1969;24:409–445.Google Scholar
  15. 15.
    Sabbah HN, Mika Y, Aviv R, Hadad W, Darvish N, Ben-Haim SA, Chaudhry P, Mishima T, Goldstein S. Delivery of non-excitatory contractility-modulation electric signals improve left ventricular performance in dogs with heart failure. Circulation 1999;100 (Suppl I): I-122(Abstract).Google Scholar
  16. 16.
    Prutchi D, Mika Y, Snir Y, Ben-Arie J, Darvish N, Kimchy Y, Ben-Haim SA. An implantable device to enhance cardiac contractility through non-excitatory signals. Circulation 1999;100 (Suppl I): I-300(Abstract).Google Scholar
  17. 17.
    Papone C, Vicedomini G, Loricchio ML, Meloni C, Salvati A, Kimchy Y, Hadad W, Aviv R, Mika Y, Darvish N, Kronzon I, Ben-Haim SA. First clinical experience demonstrating improvement of hemodynamic parameters in heart failure patients through the application of non-excitatory electrical signals. J Am Col Cardiol 2000;35 (Suppl A): A-229 (Abstract).Google Scholar
  18. 18.
    Shemer I, Folzen B, Mika Y, Haham Y, Kimchy Y, Ben-Haim SA, Darvish N. Myocardial contractility modulation using a non-excitatory electric signal. J Am Col Cardiol 1999;35 (Suppl A): A-148 (Abstract).Google Scholar
  19. 19.
    Packer M. The development of positive inotropic agents for chronic heart failure: How have we gone astray? J Am Col Cardiol 2000;22: 119A-126A.Google Scholar
  20. 20.
    Lowes BD, Simon MA, Tsvetkova TO, Bristow MR. Inotropes in the beta-blocker era. Clin Cardiol 2000;23:III-11-III-16 34 Burkhoff et al.Google Scholar

Copyright information

© Kluwer Academic Publishers 2001

Authors and Affiliations

  • Daniel BurkhoffMD PhD
    • 1
  • Itzik Shemer
    • 2
    • 3
  • Bella Felzen
    • 2
    • 3
  • Juichiro Shimizu
    • 1
  • Yuval Mika
    • 3
  • Marc Dickstein
    • 4
  • David Prutchi
    • 3
  • Nissim Darvish
    • 3
  • Shlomo A. Ben-Haim
    • 2
    • 5
  1. 1.Divisions of Circulatory Physiology and Cardiology, Cardiac Physiology Laboratory, Department of MedicineColumbia University
  2. 2.Impulse DynamicsTirat HaCarmelIsrael
  3. 3.Department of Physiology and Biophysics, The Bruce Rappaport Faculty of MedicineTechnion-Israel Institute of TechnologyHaifaIsrael
  4. 4.Department of AnesthesiologyColumbia University
  5. 5.Beth-Israel HospitalHarvard-Thorndike Arrhythmia InstituteBostonUSA

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