, Volume 5, Issue 5, pp 415–418 | Cite as

Role of reactive oxygen species (ROS) in apoptosis induction

  • H.-U. Simon
  • A. Haj-Yehia
  • F. Levi-Schaffer


Reactive oxygen species (ROS) and mitochondria play an important role in apoptosis induction under both physiologic and pathologic conditions. Interestingly, mitochondria are both source and target of ROS. Cytochrome c release from mitochondria, that triggers caspase activation, appears to be largely mediated by direct or indirect ROS action. On the other hand, ROS have also anti-apoptotic effects. This review focuses on the role of ROS in the regulation of apoptosis, especially in inflammatory cells.

apoptosis death receptors inflammation reactive oxygen species (ROS) 


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Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • H.-U. Simon
    • 1
  • A. Haj-Yehia
    • 2
  • F. Levi-Schaffer
    • 2
  1. 1.Department of PharmacologyUniversity of BernBernSwitzerland
  2. 2.Department of Pharmaceutics, School of PharmacyThe Hebrew University-Hadassah Medical SchoolJerusalemIsrael

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