Apoptosis

, Volume 4, Issue 6, pp 407–417 | Cite as

Airway epithelium and apoptosis

  • H. Jyonouchi

Abstract

Recent advances revealed that airway epithelium possesses versatile functions and plays a vital role in the mucosal defense and inflammatory responses. A maintenance of airway epithelium integrity is thus important and appears to be tightly regulated by a balanced cell proliferation and apoptosis. However, homeostasis of airway epithelium is likely affected by multiple environmental pathogens, irritants (reactive oxygen species, allergens, etc.), and toxins that may lead to various lung diseases. This review briefly summarizes airway epithelium apoptosis/proliferation in physiologic and pathological conditions along with various factors influencing airway epithelium homeostasis.

airway epithelium CD95 chemokine cytokine NO p53 polycyclic aromatic hydrocarbons (PAH) reactive oxygen species (ROS). 

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Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • H. Jyonouchi
    • 1
  1. 1.Department of PediatricsUniversity of MinnesotaMinneapolisUSA

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