IGF and Insulin Action in the Mammary Gland: Lessons from Transgenic and Knockout Models

  • Darryl L. Hadsell
  • Sharon G. Bonnette


Transgenic and knockout mice have become valuable experimental systems with which tostudy specific molecular events within the mammary gland of an intact animal. These modelshave provided a wealth of information about the effects of a number of oncogenes and growthfactors. This review focuses on results obtained from the application of transgenic and knockoutmodels to determine the roles of insulin and insulin-like growth factors (IGF)3 in the regulationof mammary gland development, lactation and tumorigenesis. Transgenic models whichoverexpress IGF-I or -II display specific alterations in mammary gland development and an increasedincidence of mammary tumors. Analysis of mammary gland development in knockout micewhich are deficient in IGF-I or the IGF-I receptor supports the conclusion that the IGF systemis important for normal mammary gland development. This review discusses these observationsin detail and attempts to fit them into a larger picture of IGF and insulin action in themammary gland.

Insulin transgenic knockout mammary IGF 


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Copyright information

© Plenum Publishing Corporation 2000

Authors and Affiliations

  • Darryl L. Hadsell
    • 1
    • 2
  • Sharon G. Bonnette
    • 1
  1. 1.USDA/ARS Children's Nutrition Research Center, Department of PediatricsBaylor College of MedicineHouston
  2. 2.USDA/ARS Children's Nutrition Research CenterHouston

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