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Chromosome Research

, Volume 6, Issue 1, pp 35–40 | Cite as

A murine TSPY

  • Tanja Vogel
  • Holly Boettger-Tong
  • Indrajit Nanda
  • Frank Dechend
  • Alexander I. Agulnik
  • Colin E. Bishop
  • Michael Schmid
  • Jorg Schmidtke
Article

Abstract

Sequences homologous to human and bovine TSPY were isolated from M. musculus testicular cDNA, and a nearly full-length gene was polymerase chain reaction (PCR) amplified from mouse genomic DNA. This gene is apparently non-functional. Contrary to the situation encountered in species along the primate and artiodactyl lineages, in which TSPY is moderately repetitive, murine Tspy appears to be single copy. Murine Tspy is located on Yp, i.e. in the same syntenic group as in man. Sequence comparisons of murine, human and bovine TSPY exons suggest that TSPY became non-functional during rodent evolution.

murine TSPY Y chromosome 

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Copyright information

© Chapman and Hall 1998

Authors and Affiliations

  • Tanja Vogel
    • 1
  • Holly Boettger-Tong
    • 2
  • Indrajit Nanda
    • 3
  • Frank Dechend
    • 1
  • Alexander I. Agulnik
    • 2
  • Colin E. Bishop
    • 2
  • Michael Schmid
    • 3
  • Jorg Schmidtke
    • 1
  1. 1.Institute of Human Genetics, Medizinische Hochschule HannoverHannoverGermany
  2. 2.Department of Obstetrics and GynecologyBaylor College of Medicine HoustonUSA
  3. 3.Institute of Human Genetics, Universitat WurzburgAm HublandGermany

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