Neuropsychology Review

, Volume 10, Issue 3, pp 151–167

Cognitive Outcome in Acute Sporadic Encephalitis

  • Laura Hokkanen
  • Jyrki Launes
Article

Abstract

Acute encephalitis is an inflammation of the brain parenchyma. In the United States, 20,000 cases occur yearly. A variety of cognitive deficits, often the sole cause of disability, may persist after the acute stage. Still, infectious diseases tend to be covered only briefly in neuropsychological handbooks. Recent literature demonstrates the heterogeneity of both amnestic disorders and the outcome following encephalitides. Herpes Simplex virus (HSV), the most common single etiology of sporadic encephalitis, usually causes the most severe symptoms. Modern antiviral medication, however, seems to improve the cognitive outcome. Much less is known about non-HSV encephalitides, where both mild and severe defects have been observed. This article summarizes the current knowledge and also calls upon a more active neuropsychological research in the area.

Encephalitis Herpes Simplex memory deficit neuropsychological assessment 

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REFERENCES

  1. Albert, M. L., Feldman, R. G., and Willis, A. L. (1974). The 'subcortical dementia' of progressive supranuclear palsy. Journal of Neurology, Neurosurgery and Psychiatry 37: 121–130.Google Scholar
  2. Alfaro, A., and Granda, D. (1991). Encefalitis por el virus de la parotiditis en el adulto [Mumps encephalitis in adulthood]. Neurologia 6: 108–110.Google Scholar
  3. Andiman, W. A., White Greenwald, M., and Tinghitella, T. (1982). Zoster encephalitis. Isolation of virus and measurement of varicellazoster-specific antibodies in cerebrospinal fluid. American Journal of Medicine 73: 769–772.Google Scholar
  4. Appelbaum, E., Kreps, S. I., and Sunshine, A. (1962). Herpes Zoster Encephalitis. American Journal of Medicine 32: 25–31.Google Scholar
  5. Baine, W. B., Luby, J. P., and Martin, S. M. (1980). Severe illness with Influenza B. American Journal of Medicine 68: 181–189.Google Scholar
  6. Barbarotto, R., Capitani, E., and Laiacona, M. (1996). Naming deficit in herpes simplex encephalitis. Acta Neurologica Scandinavica 93: 272–280.Google Scholar
  7. Bayer, W. H. (1987). Influenza B encephalitis. Western Journal of Medicine 147: 466–466.Google Scholar
  8. Beghi, E., Nicolosi, A., Kurland, L. T., Mulder, D. W., Hauser, W. A., and Shuster, L. (1984). Encephalitis and aseptic meningitis, Olmsted County, Minnesota, 1950–1981: I. Epidemiology. Annals of Neurology 16: 283–294.Google Scholar
  9. Bernstein, T. C., and Wolff, H. G. (1950). Involvement of the nervous system in infectious mononucleosis. Annals of Internal Medicine 33: 1120–1138.Google Scholar
  10. Brazzelli, M., Colombo, N., Della Sala, S., and Spinnler, H. (1994). Spared and impaired cognitive abilities after bilateral frontal damage. Cortex 30: 27–51.Google Scholar
  11. Broun, G. O., Haymaker, W., and Smith, J. E. (1958). Sequelae of the arthropod-borne encephalitides. IV St. Louis encephalitis. Neurology 8: 883–887.Google Scholar
  12. Brown, R. G., and Marsden, C. D. (1988). 'Subcortical dementia': the neuropsychological evidence. Neuroscience 25: 363–387.Google Scholar
  13. Budka, H., Urbanits, S., Liberski, P. P., Eichinger, S., and Popow Kraupp, T. (1996). Subacute measles virus encephalitis: A new and fatal opportunistic infection in a patient with AIDS. Neurology 46: 586–587.Google Scholar
  14. Buttner, T., and Dorndorf, W. (1988). Virale Enzephalitiden. Erfarungen mit 53 Patienten aus Mittelhessen [Viral encephalitis. Experiences with 53 patients in Middle Hessia]. Fortschr. Neurol Psychiatr. 56: 315–325.Google Scholar
  15. Calabrese, P., Markowitsch, H. J., Durwen, H. F., Widlitzek, H., Haupts, M., Holinka, B., and Gehlen, W. (1996). Right temporofrontal cortex as critical locus for the ecphory of old episodic memories. Journal of Neurology, Neurosurgery and Psychiatry 61: 304–310.Google Scholar
  16. Caparros-Lefebvre, D., Girard-Buttaz, I., Reboul, S., Lebert, F., Cabaret, M., Verier, A., Steinling, M., Pruvo, J. P., and Petit, H. (1996). Cognitive and psychiatric impairment in herpes simplex virus encephalitis suggest involvement of the amygdalo-frontal pathways. Journal of Neurology 243: 248–256.Google Scholar
  17. Cermak, L. S. (1976). The encoding capacity of a patient with amnesia due to encephalitis. Neuropsychologia 14: 311–326.Google Scholar
  18. Cermak, L. S. (1984). The episodic-semantic distinction in amnesia. In Squire, L. R., and Butters, N. (eds.), Neuropsychology of Memory, Guildford Press, New York, pp. 52–62.Google Scholar
  19. Cermak, L. S., Blackford, S. P., O'Connor, M., and Bleich, R. P. (1988). The implicit memory ability of a patient with amnesia due to encephalitis. Brain and Cognition 7: 145–156.Google Scholar
  20. Cermak, L. S., and O'Connor, M. (1983). The anterograde and retrograde retrieval ability of a patient with amnesia due to encephalitis. Neuropsychologia 21: 213–234.Google Scholar
  21. Chou, S. M., Roos, R., Burrell, R., Gutmann, L., and Harley, J. B. (1973). Subacute focal adenovirus encephalitis. Journal of Neuropathology and Experimental Neurology 32: 34–50.Google Scholar
  22. Conlon, P., Kertesz, A., and Mount, J. (1988). Kluver Bucy syndrome with severe amnesia secondary to herpes encephalitis. Canadian Journal of Psychiatry 33: 754–756.Google Scholar
  23. Croft, P. B. (1969). Para-infectious and post-vaccinal encephalomyelitis. Postgraduate Medical Journal 45: 392–400.Google Scholar
  24. Cummings, J. L., and Benson, D. F. (1984). Subcortical dementia. Review of an emerging concept. Archives of Neurology 41: 874–879.Google Scholar
  25. Dam, M. (1992). Localization related epileptic syndromes. In Trimble, M. R., and Bolwig, T. G. (eds.), The Temporal Lobes and the Limbic System, Wrightson Biomedical Publishing Ltd., Petersfield, pp. 115–127.Google Scholar
  26. Damasio, H., and Damasio, A. R. (1989). Lesion Analysis in Neuropsychology, Oxford University Press, New York.Google Scholar
  27. Damasio, A. R., Eslinger, P. J., Damasio, H., Van Hoesen, G. W., and Cornell, S. (1985). Multimodal amnesic syndrome following bilateral temporal and basal forebrain damage. Archives of Neurology 42: 252–259.Google Scholar
  28. Damasio, A. R., and Tranel, D. (1990). Knowing that 'Colorado' goes with 'Denver' does not imply knowledge that 'Denver' is in 'Colorado.' Behavioral Brain Research 40: 193–200.Google Scholar
  29. Damasio, A. R., Tranel, D., and Damasio, H. (1989). Amnesia caused by herpes simplex encephalitis, infarctions in basal forebrain, Alzheimer's disease and anoxia/ischemia. In Boller, F., and Grafman, J. (eds.), Handbook of Neuropsychology, Vol. 3. Elsevier, Amsterdam, pp. 149–166.Google Scholar
  30. Damasio, A. R., and Van Hoesen, G. W. (1985). The limbic system and the localisation of herpes simplex encephalitis. Journal of Neurology Neurosurgery and Psychiatry 48: 297–301.Google Scholar
  31. Davis, L. E., and Johnson, R. T. (1979). An explanation for the localization of herpes simplex encephalitis? Annals of Neurology 5: 2–5.Google Scholar
  32. de Wytt, C. N., Dickson, P. L., and Holt, G. W. (1982). Cryptococcal meningitis. A review of 32 years experience. Journal of Neurological Sciences 53: 283–292.Google Scholar
  33. Della Sala, S., Laiacone, M., Spinnler, H., and Trivelli, C. (1993). Autobiographical recollection and frontal damage. Neuropsychologia 31: 823–839.Google Scholar
  34. Dickerson, R. B., Newton, J. R., and Hansen, J. E. (1952). Diagnosis and immediate prognosis of Japanese B encephalitis. Observations based on more than 200 patients with detailed analysis of 65 serologically confirmed cases. American Journal of Medicine 12: 277–288.Google Scholar
  35. Dikmen, S., and Matthews, C. G. (1977). Effect of major motor seizure frequency upon cognitive-intellectual functions in adults. Epilepsia 18: 21–29.Google Scholar
  36. Dodrill, C. B. (1986). Correlates of generalized tonic-clonic seizures with intellectual, neuropsychological, emotional and social function in patients with epilepsy. Epilepsia 27: 399–411.Google Scholar
  37. Drachman, D. A., and Adams, R. D. (1962). Herpes simplex and acute inclusion-body encephalitis. Archives of Neurology 7: 61–79.Google Scholar
  38. Enzmann, D. R., Ranson, B., Norman, D., and Talberth, E. (1978). Computed tomography of herpes simplex encephalitis. Radiology 129: 419–425.Google Scholar
  39. Erickson, K. R. (1990). Amnestic disorders. Pathophysiology and patterns of memory dysfunction. Western Journal of Medicine 152: 159–166.Google Scholar
  40. Eslinger, P. J., Damasio, H., Damasio, A. R., and Butters, N. (1993). Nonverbal amnesia and asymmetric cerebral lesions following encephalitis. Brain and Cognition 21: 140–152.Google Scholar
  41. Evengård, B., Schacterle, R. S., and Komaroff, A. L. (1999). Chronic fatigue syndrome: New insights and old ignorance. Journal of Internal Medicine 246: 455–469.Google Scholar
  42. Flewett, T. H., and Hoult, J. G. (1958). Influenzal encephalopathy and postinfluenzal encephalitis. Lancet 2: 11–15.Google Scholar
  43. Galbraith, N. S., Young, S. E., Pusey, J. J., Crombie, D. L., and Sparks, J. P. (1984). Mumps surveillance in England and Wales 1962–81. Lancet I: 91–94.Google Scholar
  44. Garrard, P., Perry, R., and Hodges, J. R. (1997). Disorders of semantic memory. Journal of Neurology, Neurosurgery and Psychiatry 62: 431–435.Google Scholar
  45. Gaudino, E. A., Coyle, P. K., and Krupp, L. B. (1997). Post-Lyme syndrome and chronic fatigue syndrome. Neuropsychiatric similarities and differences. Archives of Neurology 54: 1372–1376.Google Scholar
  46. Gershon, A., Steinberg, S., Greenberg, S., and Taber, L. (1980). Varicellazoster-associated encephalitis: Detection of specific antibody in cerebrospinal fluid. Journal of Clinical Microbiology 12: 764–767.Google Scholar
  47. Gjerstad, L., Nyberg Hansen, R., Bjorland, O., Nakstad, P., Russell, D., and Rootwelt, K. (1986). Herpes zoster ophthalmicus with cerebral angiitis and reduced cerebral blood flow. Acta Neurologica Scandinavica 74: 460–466.Google Scholar
  48. Goldberg, E., Antin, S. P., Bilder, R. M., Jr., Gerstman, L. J., Hughes, J. E., and Mattis, S. (1981). Retrograde amnesia: Possible role of mesencephalic reticular activation in long-term memory. Science 213: 1392–1394.Google Scholar
  49. Gordon, B., Selnes, O. A., Hart, J. J., Hanley, D. F., and Whitley, R. J. (1990). Long-term cognitive sequelae of acyclovir-treated herpes simplex encephalitis. Archives of Neurology 47: 646–647.Google Scholar
  50. Graham, K. S., and Hodges, J. R. (1997). Differentiating the roles of the hippocampal complex and the neocortex in long-term memory storage: Evidence from the study of semantic dementia and Alzheimer's disease. Neuropsychology 11: 77–89.Google Scholar
  51. Greenwood, R., Bhalla, A., Gordon, A., and Roberts, J. (1983). Behaviour disturbances during recovery from herpes simplex encephalitis. Journal of Neurology, Neurosurgery and Psychiatry 46: 809–817.Google Scholar
  52. Griffin, D., and Johnson, R. T. (1990). Encephalitis, myelitis, and neuritis. In Mandell, G. L., Douglas, R. G., and Bennett, J. E. (eds.), Principles and Practice of Infectious Diseases Churchill Livingtone Inc., New York, pp. 762–769.Google Scholar
  53. Grose, C., Henle, W., Henle, G., and Feorino, P. M. (1975). Primary Epstein-Barr-virus infections in acute neurologic diseases. New England Journal of Medicine 292: 392–395.Google Scholar
  54. Guess, H. A., Broughton, D. D., Melton, L. J., and Kurland, L. T. (1986). Population-based studies of varicella complications. Pediatrics 78: 723–727.Google Scholar
  55. Hall, P. (1963). Korsakov's syndrome following Herpes-Zoster encephalitis. Lancet 1: 752–752.Google Scholar
  56. Halonen, P. E., Rimon, R., Arohonka, K., and Jäntti, V. (1974). Antibody levels to herpes simplex type I, measles and rubella viruses in psychiatric patients. British Journal of Psychiatry 125: 461–465.Google Scholar
  57. Halperin, J. J. (1998). Nervous system Lyme disease. Journal of Neurological Sciences 153: 182–191.Google Scholar
  58. Hanley, D. F., Johnson, R. T., and Whitley, R. J. (1987). Yes, brain biopsy should be a prerequisite for herpes simplex encehalitis treatment. Archives of Neurology 44: 1289–1290.Google Scholar
  59. Hart, M. N., and Earle, K. M. (1975). Haemorrhagic and perivenous encephalitis: A clinical-pathological review of 38 cases. Journal of Neurology, Neurosurgery and Psychiatry 38: 585–591.Google Scholar
  60. Hart, R. P., Kwentus, J. A., Frazier, R. B., and Hormel, T. L. (1986). Natural history of Kluver-Bucy syndrome after treated herpes encephalitis. Southern Medical Journal 79: 1376–1378.Google Scholar
  61. Hawkins, S. A., Lyttle, J. A., and Connolly, J. H. (1987). Two cases of in-fluenza B encephalitis [letter]. Journal of Neurology, Neurosurgery and Psychiatry 50: 1236–1237.Google Scholar
  62. Hierons, R., Janota, I., and Corsellis, J. A. (1978). The late effects of necrotizing encephalitis of the temporal lobes and limbic areas: A clinico-pathological study of 10 cases. Psychological Medicine 8: 21–42.Google Scholar
  63. Ho, D. D., and Hirsch, M. S. (1985). Acute viral encephalitis. Med. Clin. North Am. 69: 415–429.Google Scholar
  64. Hochberg, F., Nelson, K., and Janzen, W. (1975). Influenza type B-related encephalopathy. The 1971 outbreak of Reye syndrome in Chicago. JAMA 231: 817–821.Google Scholar
  65. Hokkanen, L., and Launes, J. (1995). Isolated retrograde amnesia for autobiographical material associated with acute left temporal lobe encephalitis. Psychological Medicine 25: 203–208.Google Scholar
  66. Hokkanen, L., and Launes, J. (1997). Cognitive recovery instead of decline after acute encephalitis: A prospective follow up study. Journal of Neurology, Neurosurgery and Psychiatry 63: 222–227.Google Scholar
  67. Hokkanen, L., Launes, J., Poutiainen, E., Valanne, L., Salonen, O., Sirén, J., and Iivanainen, M.(1997). Subcortical type cognitive impairment in herpes zoster encephalitis. Journal of Neurology 244: 239–245.Google Scholar
  68. Hokkanen, L., Poutiainen, E., Valanne, L., Salonen, O., and Launes, J. (1996a). Cognitive impairment after acute encephalitis: Comparison of herpes simplex and other aetiologies. Journal of Neurology, Neurosurgery and Psychiatry 61: 478–484.Google Scholar
  69. Hokkanen, L., Salonen, O., and Launes, J. (1996b). Amnesia in acute herpetic and nonherpetic encephalitis. Archives of Neurology 53: 972–978.Google Scholar
  70. Horten, B., Price, R. W., and Jimenez, D. (1981). Multifocal varicellazoster virus leukoencephalitis temporally remote from herpes zoster. Annals of Neurology 9: 251–266.Google Scholar
  71. Huber, M., Ziffling, P., Heucke, T., and Heiss, W. D. (1989). Verlauf und Prognose der Herpes-simplex-Enzephalitis. Beobachtungen an 57 Patients zwischen 1060 und 1987 [Clinical course and prognosis of herpes simplex encephalitis: Observation of 57 patients between 1960 and 1987]. Medizinische Klinik 84: 273–275.Google Scholar
  72. Hughes, B. A., Kimmel, D.W., and Aksamit, A. J. (1993). Herpes zoster-associated meningoencephalitis in patients with systemic cancer. Mayo Clinical Proceedings 68: 652–655.Google Scholar
  73. Jemsek, J., Greenberg, S. B., Taber, L., Harvey, D., Gershon, A., and Couch, R. B. (1983). Herpes zoster-associated encephalitis: Clinicopathologic report of 12 cases and review of the literature. Medicine Baltimore 62: 81–97.Google Scholar
  74. Johnson, R. T. (1986). Response of the nervous system to infection. In Asbury, A. K., McKhann, G. M., and McDonald, W. I. (eds.), Diseases of the Nervous System. Clinical Neurobiology, W.B. Saunders Company, Philadelphia, pp. 1341–1351.Google Scholar
  75. Jouanny, P., Vespignani, H., Gérard, A., Jeandel, C., Ducrocq, X., Penin, F., Weber, M., Dureux, J. B., Cuny, G., and Canton, P. (1994). Méningoencéphalite herpétique du sujet âgé. A propos de 13 observations. [Herpetic encephalitis in the elderly. A report of 13 cases.]. Revue de Médicine Interne 15: 504–509.Google Scholar
  76. Kaplan, R. F., Jones-Woodward, L., Workman, K., Steere, A. C., Logigian, E. L., and Meadows, M. E. (1999). Neuropsychological deficits in Lyme disease patients with and without other evidence of central nervous system pathology. Applied Neuropsychology 6: 3–11.Google Scholar
  77. Kapur, N., Barker, S., Burrows, E. H., Ellison, D., Brice, J., Illis, L. S., Scholey, K., Colbourn, C., Wilson, B., and Loates, M. (1994). Herpes simplex encephalitis: Long term magnetic resonance imaging and neuropsychological profile. Journal of Neurology, Neurosurgery and Psychiatry 57: 1334–1342.Google Scholar
  78. Kapur, N., Ellison, D., Smith, M. P., McLellan, D. L., and Burrows, E. H. (1992). Focal retrograde amnesia following bilateral temporal lobe pathology. A neuropsychological and magnetic resonance study. Brain 115: 73–85.Google Scholar
  79. Keidan, I., Shif, I., Keren, G., and Passwell, J. H. (1992). Rotavirus encephalopathy: Evidence of central nervous system involvement during rotavirus infection. Pediatric Infectious Disease Journal 11: 773–775.Google Scholar
  80. Kelsey, D. S., and McLean, W. T. (1979). Adenoviral meningoencephalitis in a patient with lead toxicity. Archives of Neurology 36: 384–385.Google Scholar
  81. Kennard, C., and Swash, M. (1981). Acute viral encephalitis: Its diagnosis and outcome. Brain 104: 129–148.Google Scholar
  82. Kennedy, P. G. (1988). A retrospective analysis of forty-six cases of herpes simplex encephalitis seen in Glasgow between 1962 and 1985. Quarterly Journal of Medicine 68: 533–540.Google Scholar
  83. Klapper, P. E., Cleator, G. M., and Longson, M. (1984). Mild forms of herpes encephalitis. Journal of Neurology, Neurosurgery and Psychiatry 47: 1247–1250.Google Scholar
  84. Klapper, P. E., Laing, I., and Longson, M. (1981). Rapid non-invasive diagnosis of Herpes encephalitis. Lancet 2: 607–609.Google Scholar
  85. Kleinschmidt-DeMasters, B., Amlie-Lefond, C., and Gilden, D. (1996). The patterns of varicella zoster virus encephalitis. HumanPathology 27: 927–938.Google Scholar
  86. Klemola, E., Kääriäinen, L., Ollila, O., Pettersson, T., Jansson, E., Haapanen, L., Lapinleimu, K., and Forssell, P. (1965). Studies on viral encephalitis. Acta Medica Scandinavica 177: 707–716.Google Scholar
  87. Kluver, H., and Bucy, P. C. (1939). Preliminary analysis of functions of the temporal lobes in monkeys. Archives of Neurology and Psychiatry 42: 979–1000.Google Scholar
  88. Kopelman, M. D. (1991). Frontal dysfunction and memory deficits in the alcoholic Korsakoff syndrome and Alzheimer-type dementia. Brain 114: 117–137.Google Scholar
  89. Koskiniemi, M. L., and Ketonen, L. (1981). Herpes simplex virus encephalitis: Progression of lesion shown by CT. Journal of Neurology 225: 9–13.Google Scholar
  90. Koskiniemi, M.L., Manninen, V., Vaheri, A., Sainio, K., Eistola, P., and Karli, P. (1981). A cute encephalitis. A survey of epidemiological clinical and microbiological features coveringa twelve-year period. Acta Medica Scandinavica209: 115–120Google Scholar
  91. Kotila, M., Waltimo, O., Niemi, M. L., and Laaksonen, R. (1986). Dementia after stroke. European Neurology 25: 134–140.Google Scholar
  92. Ladurner, G., Iliff, L. D., and Lechner, H. (1982). Clinical factors associated with dementia in ischaemic stroke. Journal of Neurology, Neurosurgery and Psychiatry 45: 97–101.Google Scholar
  93. Launes, J., Paetau, A., Linnavuori, K., and Iivanainen, M. (1997). Direct invasion of the brain parenchyma by Mycoplasma pneumoniae. Acta Neurologica Scandinavica 95: 374–374.Google Scholar
  94. Laurent, B., Allegri, R. F., Thomas-Anterion, C., Foyatier, N., Naegele-Faure, B., and Pellat, J. (1991). Long-term neuropsychological follow-up in patients with herpes simplex encephalitis and predominantly left-sided lesions. Behavioural Neurology 4: 211–224.Google Scholar
  95. Leng, N. R., and Parkin, A. J. (1988). Double dissociation of frontal dysfunction in organic amnesia. British Journal of Clinical Psychology 27: 359–362.Google Scholar
  96. Lentz, D., Jordan, J. E., Pike, G. B., and Enzmann, D. R. (1993). MRI in varicella-zoster virus leukoencephalitis in the immunocompromised host. Journal of Computer Assisted Tomography 17: 313–316.Google Scholar
  97. Lewis, J. L., and Rabinovich, S. (1972). The wide spectrum of cryptococcal infections. American Journal of Medicine 53: 315–322.Google Scholar
  98. Lindsberg, P., Pieninkeroinen, I., and Valtonen, M. (1997). Meningoencephalitis caused by cryptococcus macerans. Scandinavian Journal of Infectious Diseases 29: 430–433.Google Scholar
  99. Linnemann, C. C., Jr., First, M. R., Alvira, M. M., Alexander, J. W., and Schiff, G. M. (1976). Herpesvirus hominis type 2 meningoencephalitis following renal transplantation. American Journal of Medicine 61: 703–708.Google Scholar
  100. Lloyd Still, R. M. (1958). Psychosis following Asian influenza. Lancet 2: 20–21.Google Scholar
  101. Lycke, E., Norrby, R., and Roos, B. E. (1974). A serological study on mentally ill patients-with particular reference to the prevalence of herpes virus infections. British Journal of Psychiatry 124: 273–279.Google Scholar
  102. Mäkelä, O., Tiilikainen, A., Vaara, M., Vaheri, A., and Valtonen, V. (1993). Lääketieteellinen mikrobiologia [Medical microbiology]. Duodecim, Helsinki.Google Scholar
  103. Mahalingam, R., Wellish, M. C., Dueland, A. N., Cohrs, R. J., and Gilden, D. H. (1992). Localization of herpes simplex virus and varicella zoster virus DNA in human ganglia. Annals of Neurology 31: 444–448.Google Scholar
  104. Markowitsch, H. J., Calabrese, P., Liess, J., Haupts, M., Durwen, H. F., and Gehlen, W. (1993). Retrograde amnesia after traumatic injury of the fronto-temmporal cortex. Journal of Neurology, Neurosurgery and Psychiatry 56: 988–992.Google Scholar
  105. Martin, A., Wiggs, C. L., Ungerleider, L. G., and Haxby, J. V. (1996). Neural correlates of category-specific knowledge. Nature 379: 649–652.Google Scholar
  106. Marton, R., Gotlieb-Steimatsky, T., Klein, C., and Arlazoroff, A. (1996). Acute herpes simplex encephalitis: Clinical assessment and prognostic data. Acta Neurologica Scandinavica 93: 149–155.Google Scholar
  107. Mauri, A., Daum, I., Sartori, G., Riesch, G., and Birbaumer, N. (1994). Category-specific semantic impairment in Alzheimer's disease and temporal lobe dysfunction:Acomparative study. Journal of Clinical and Experimental Neuropsychology 16: 689–701.Google Scholar
  108. Mazur, M. H., and Dolin, R. (1978). Herpes zoster at the NIH: A 20 year experience. American Journal of Medicine 65: 738–744.Google Scholar
  109. McCarthy, R., Evans, J., and Hodges, J. (1996). Topographic amnesia: Spatial memory disorder, perceptual dysfunction, or category specific semantic memory impairment. Journal of Neurology, Neurosurgery and Psychiatry 60: 318–325.Google Scholar
  110. McCarthy, R. A., and Warrington, E. K. (1992). Actors but not scripts: The dissociation of people and events in retrograde amnesia. Neuropsychologia 30: 633–644.Google Scholar
  111. McClelland, J. L., McNaughton, B. L., and O'Reilly, R. C. (1995). Why there are complementary learning systems in the hippocampus and neocortex: Insights from the successes and failures of connectionist models of learning and memory. Psychological Review 102: 419–457.Google Scholar
  112. McConkey, B., Oxon, B. M., and Daws, R. A. (1958). Neurological disorders associated with Asian influenza. Lancet 2: 15–17.Google Scholar
  113. McCutchan, J. A. (1995). Clinical impact of cytomegalovirus infection of the nervous system in patients with AIDS. Clinical Infectious Diseases 21: 196–201.Google Scholar
  114. McGrath, N., Anderson, N. E., Croxson, M. C., and Powell, K. F. (1997). Herpes simplex encephalitis treated with acyclovir: Diagnosis and long term outcome. Journal of Neurology, Neurosurgery and Psychiatry 63: 321–326.Google Scholar
  115. McKenna, K. F., and Warneke, L. B. (1992). Encephalitis associated with herpes zoster: A case report and review. Canadian Journal of Psychiatry 37: 271–273.Google Scholar
  116. Mehta, Z., Newcombe, F., and De Haan, E. (1992). Selective loss of imagery in a case of visual agnosia. Neuropsychologia 30: 645–655.Google Scholar
  117. Meyer, H. M., Johnson, R. T., Crawford, I. P., Dascomb, H. E., and Rogers, N. G. (1960). Central Nervous System Syndromes of “Viral” Etiology. A study of 713 cases. American Journal of Medicine 29: 334–347.Google Scholar
  118. Miller, J. D., and Ross, C. A. (1968). Encephalitis. A four-year survey. Lancet 1: 1121–1126.Google Scholar
  119. Miller, H. G., Stanton, J. B., and Gibbons, J. L. (1956). Para-infectious encephalomyelitis and related syndromes: A critical review of the neurological complications of certain specific fevers. Quarterly Journal of Medicine 25: 427–505.Google Scholar
  120. Morgello, S., Block, G. A., Price, R. W., and Petito, C. K. (1988). Varicella-zoster virus leukoencephalitis and cerebral vasculopathy. Archives of Pathology and Laboratory Medicine 112: 173–177.Google Scholar
  121. Morrison, R. E., Miller, M. H., Lyon, L. W., Griffiss, J. M., and Artenstein, M. S. (1974). Adult meningoencephalitis caused by herpesvirus hominis type 2. American Journal of Medicine 56: 540–544.Google Scholar
  122. Mouritzen Dam, A. (1980). Epilepsy and neuron loss in the hippocampus. Epilepsia 21: 617–629.Google Scholar
  123. Nishimura, S., Ushijima, H., Shiraishi, H., Kanazawa, C., Abe, T., Kaneko, K., and Fukuyama, Y. (1993). Detection of rotavirus in cerebrospinal fluid and blood of patients with convulsions and gastroenteritis by means of the reverse transcription polymerase chain reaction. Brain and Development 15: 457–459.Google Scholar
  124. Norris, F. H., Jr., Leonards, R., Calanchini, P. R., and Calder, C. D. (1970). Herpes-zoster meningoencephalitis. Journal of Infectious Diseases 122: 335–338.Google Scholar
  125. O'Connor, M., Butters, N., Miliotis, P., Eslinger, P., and Cermak, L. S. (1992). The dissociation of anterograde and retrograde amnesia in a patient with herpes encephalitis. Journal of Clinical and Experimental Neuropsychology 14: 159–178.Google Scholar
  126. Olson, L. C., Buescher, E. L., Artenstein, M. S., and Parkman, P. D. (1967). Herpesvirus infections of the human central nervous system. New England Journal of Medicine 277: 1271–1277.Google Scholar
  127. Oommen, K. J., Johnson, P. C., and Ray, C. G. (1982). Herpes simplex type 2 virus encephalitis presenting as psychosis. American Journal of Medicine 73: 445–448.Google Scholar
  128. Oxbury, J. M., and MacCallum, F. O. (1973). Herpes simplex virus encephalitis: Clinical features and residual damage. Postgraduate Medical Journal 49: 387–389.Google Scholar
  129. Pantoni, L., Inzitari, D., Colao, M. G., De Mayo, E., Marini, P., and Mazzota, F. (1991). Cytomegalovirus encephalitis in a non-immunocompromised patient: CSF diagnosis by in situ hybridization cells. Acta Neurologica Scandinavica 84: 56–58.Google Scholar
  130. Patterson, K., and Hodges, J. R. (1995). Disorders of semantic memory. In Baddeley, A. D., Wilson, B. A., and Watts, F. N. (eds.), Handbook of Memory Disorders, John Wiley & Sons Ltd., Chichester, pp. 167–186.Google Scholar
  131. Peterslund, N. A. (1988). Herpes zoster associated encephalitis: Clinical findings and acyclovir treatment. Scandinavian Journal of Infectious Diseases 20: 583–592.Google Scholar
  132. Pietrini, V., Nertempi, P., Vaglia, A., Revello, M. G., Pinna, V., and Ferro Milone, F. (1988). Recovery from herpes simplex encephalitis: Selective impairment of specific semantic categories with neuroradiological correlation. Journal of Neurology, Neurosurgery and Psychiatry 51: 1284–1293.Google Scholar
  133. Pohjasvaara, T., Erkinjuntti, T., Vataja, R., and Kaste, M. (1997). Dementia three months after stroke. Baseline frequency and effect of different definitions of dementia in the Helsinki stroke aging memory study (SAM) cohort. Stroke 28: 785–792.Google Scholar
  134. Pommer, B., Pilz, P., and Harrer, G. (1983). Transient global amnesia as a manifestation of Epstein-Barr virus encephalitis. Journal of Neurology 229: 125–127.Google Scholar
  135. Pönkä, A. (1979). The occurrence and clinical picture of serologically verified Mycoplasma pneumoniae infections with emphasis on central nervous system, cardiac and joint manifestations. Annals of Clinical Research 11 Suppl 24: 1–60.Google Scholar
  136. Reshef, E., Greenberg, S. B., and Jankovic, J. (1985). Herpes zoster ophthalmicus followed by contralateral hemiparesis: Report of two cases and review of literature. Journal of Neurology, Neurosurgery and Psychiatry 48: 122–127.Google Scholar
  137. Rimon, R., and Halonen, P. (1969). Herpes simplex virus infection and depressive illness. Diseases of the Nervous System 30: 338–340.Google Scholar
  138. Rose, C. F., Brett, E. M., and Burston, J. (1964). Zoster Encephalomyelitis. Archives of Neurology 11: 155–172.Google Scholar
  139. Rose, F. C., and Symonds, C. P. (1960). Persistent memory defect following encephalitis. Brain 83: 195–212.Google Scholar
  140. Rousseau, F., Perronne, C., Deny, P., Mestassi, R., Laraki, H., Marche, C., Leport, C., and Vilde, J. L. (1993). Prolonged and fatal disseminated cytomegalovirus infection in an immunocompetent woman. European Journal of Clinical Microbiology and Infectious Diseases 12: 938–940.Google Scholar
  141. Ruff, R. M., Young, D., Gautille, T., Marshall, L. F., Barth, J., Jane, J. A., Kreutzer, J., Marmarou, A., Levin, H. S., Eisenberg, H. M., and Foulkes, M. A. (1991). Verbal learning deficits following severe head injury: Heterogeneity in recovery over 1 year. Journal of Neurosurgery 75: S50-S58Google Scholar
  142. Sartori, G., Job, R., Miozzo, M., Zago, S., and Marchiori, G. (1993). Category-specific form-knowledge deficit in a patient with herpes simplex virus encephalitis. Journal of Clinical and Experimental Neuropsychology 15: 280–299.Google Scholar
  143. Schlitt, M., Lakeman, F. D., and Whitley, R. J. (1985). Psychosis and herpes simplex encephalitis. Southern Medical Journal 78: 1347–1350.Google Scholar
  144. Seidenberg, M., O'Leary, D. S., Berent, S., and Boll, T. (1981). Changes in seizure frequency and test-retest scores on the Wechsler Adult Intelligence Scale. Epilepsia 22: 75–83.Google Scholar
  145. Semenza, C., and Bisiacchi, P. S. (1996). Warrington and Shallice's (1984) category-specific aphasic J. B. R. In Code, C., Wallesch, C. W., Joanette, Y., and Roch Lecours, A. (eds.), Classic Cases in Neuropsychology, Psychology Press, Hove, pp. 217–231.Google Scholar
  146. Shoqeirat, M. A., Mayes, A., MacDonald, C., Meudell, P., and Pickering, A. (1990). Performance on tests sensitive to frontal lobe lesions by patients with organic amnesia: Leng and Parkin revisited. British Journal of Clinical Psychology 29: 401–408.Google Scholar
  147. Silverstein, A., Steinberg, G., and Nathanson, M. (1972). Nervous system involvement in infectious mononucleosis. The heralding and-or major manifestation. Archives of Neurology 26: 353–358.Google Scholar
  148. Sivertsen, B., and Christensen, P. B. (1996). Acute encephalitis. Acta Neurologica Scandinavica 93: 156–159.Google Scholar
  149. Sk¨oldenberg, B. (1991). Herpes Simplex Encephalitis. Scandinavian Journal of Infectious Diseases Suppl. 78: 40–46.Google Scholar
  150. Sköldenberg, B., Forsgren, M., Alestig, K., Bergström, T., Burman, L., Dahlqvist, E., Forkman, A., Fryden, A., Lövgren, K., Norlin, K., et al. (1984). Acyclovir versus vidarabine in herpes simplex encephalitis. Randomised multicentre study in consecutive Swedish patients. Lancet 2: 707–711.Google Scholar
  151. Snowden, J. S., Goulding, P. J., and Neary, D. (1989). Semantic dementia: A form of circumscribed cerebral atrophy. Behavioural Neurology 2: 167–182.Google Scholar
  152. Snowden, J. S., Griffits, H. L., and Neary, D. (1996). Semantic-episodic memory interactions in semantic dementia: Implications for retrograde memory function. Cognitive Neuropsychology 13: 1101–1137.Google Scholar
  153. Squire, L. R., and Zola Morgan, S. (1991). The medial temporal lobe memory system. Science 253: 1380–1386.Google Scholar
  154. Sterner, G., and Biberfeld, G. (1969). Central nervous system complications of Mycoplasma pneumoniae infection. Scandinavian Journal of Infectious Diseases 1: 203–208.Google Scholar
  155. Stoler, M., Meshulam, B., Zoldan, J., and Sirota, P. (1987). Schizophreniform episode following measles infection. British Journal of Psychiatry 150: 861–862.Google Scholar
  156. Studahl, M., Ricksten, A., Sandberg, T., Bergström, T., and Elowson, S. (1992). Cytomegalovirus encephalitis in four immunocompetent patients. Lancet 340: 1045–1046.Google Scholar
  157. Sulkava, R., Rissanen, A., and Pyhala, R. (1981). Post-influenzal encephalitis during the influenza A outbreak in 1979/1980. Journal of Neurology, Neurosurgery and Psychiatry 44: 161–163.Google Scholar
  158. Sutton, A. L., Smithwick, E. M., Seligman, S. J., and Kim, D. S. (1974). Fatal disseminated herpesvirus hominis type 2 infection in an adult with associated thymic dysplasia. American Journal of Medicine 56: 545–553.Google Scholar
  159. Tanaka, Y., Miyazawa, Y., Hashimoto, R., Nakano, I., and Obayashi, T. (1999). Postencephalitic focal retrograde amnesia after bilateral anterior temporal lobe damage. Neurology 53: 344–350.Google Scholar
  160. ter Meulen, V., Muller, D., Käckell, Y., Katz, M., and Meyermann, R. (1972). Isolation of infectious measles virus in measles encephalitis. Lancet II: 1172–1175.Google Scholar
  161. Tiersky, L. A., Johnson, S. K., Lange, G., Natelson, B. H., and DeLuca, J. (1997). Neuropsychology of chronic fatigue syndrome: A critical review. Journal of Clinical and Experimental Neuropsychology 19: 560–586.Google Scholar
  162. Tong, C. Y. W., Potter, F. A., Pang, K. A., and Vora, J. (1997). Severe encephalitis with rapid recovery. Lancet I: 470–470.Google Scholar
  163. Townsend, J. J., Wolinsky, J. S., and Baringer, J. R. (1976). The neuropathology of progressive rubella panencephalitis of late onset. Brain 99: 81–90.Google Scholar
  164. Tranel, D., and Damasio, A. R. (1993). The covert learning of affective valence does not require structures in hippocampal system or amygdala. Journal of Cognitive Neuroscience 5: 79–88.Google Scholar
  165. Tranel, D., and Damasio, A. R. (1995). Neurobiological foundations of human memory. In Baddeley, A. D., Wilson, B. A., and Watts, F. N. (eds.), Handbook of Memory Disorders, John Wiley and Sons Ltd., Chichester, pp. 27–50.Google Scholar
  166. Treib, J., Fernandez, A., Haass, A., Grauer, M. T., Holzer, G., and Woessner, R. (1998). Clinical and serologic follow-up in patients with neuroborreliosis. Neurology 51: 1489–1491.Google Scholar
  167. Tulving, E. (1972). Episodic and semantic memory. In Tulving, E., and Donaldson W. (eds.), Organization of Memory, Academic Press, New York, pp. 382–404.Google Scholar
  168. Twomey, J. A., and Jefferson, D. (1981). Encephalitis and polyneuritis complicating varicella zoster infection. Postgraduate Medical Journal 57: 507–508.Google Scholar
  169. Utley, T. F., Ogden, J. A., Gibb, A., McGrath, N., and Anderson, N. E. (1997). The long-term neuropsychological outcome of herpes simplex encephalitis in a series of unselected survivors. Neuropsychiatry, Neuropsychology, and Behavioral Neurology 10: 180–189.Google Scholar
  170. Vaheri, A., Julkunen, I., and Koskiniemi, M. L. (1982). Chronic encephalomyelitis with specific increase in intrathecal mumps antibodies. Lancet II: 685–688.Google Scholar
  171. Vercoulen, J. H., Bazelmans, E., Swanink, C. M., Galama, J. M., Fennis, J. F., van der Meer, J. W., and Bleijenberg, G. (1998). Evaluating neuropsychological impairment in chronic fatigue syndrome. Journal of Clinical and Experimental Neuropsychology 20: 144–156.Google Scholar
  172. Verfaellie, M., Croce, P., and Milberg, W. P. (1995). The role of episodic memory in semantic learning: An examination of vocabulary acquisition in a patient with amnesia due to encephalitis. Neurocase 1: 291–304.Google Scholar
  173. Vinters, H. V., Kwok, M. K., Ho, H. W., Anders, K. H., Tomiyasu, U., Wolfson, W. L., and Robert, F. (1989). Cytomegalovirus in the nervous system of patients with the acquired immune defiency syndrome. Brain 112: 245–268.Google Scholar
  174. Warrington, E. K., and McCarthy, R. A. (1988). The fractionation of retrograde amnesia. Brain and Cognition 7: 184–200.Google Scholar
  175. Warrington, E. K., and Shallice, T. (1984). Category specific semantic impairments. Brain 107: 829–854.Google Scholar
  176. Weaver, O. M., Haymaker, W., Pieper, S., and Kurland, R. (1958). Sequelae of the arthropod-borne encephalitis. V Japanese encephalitis. Neurology 8: 887–889.Google Scholar
  177. Weenink, H. R., and Bruyn, G. W. (1978). Cryptococcosis of the nervous system. In Vinken, P. J., and Bruyn, G. W. (eds.), Handbook of Clinical Neurology, Elsevier/North-Holland Biomedical Press, Amsterdam, pp. 459–502.Google Scholar
  178. Wells, C. E. C. (1971). Neurological complications of so-called “In-fluenza.” A winter study in South-east Wales. British Medical Journal 1: 369–373.Google Scholar
  179. Wessely, S. (1991). Chronic fatigue syndrome. editorial. Journal of Neurology, Neurosurgery and Psychiatry 54: 669–671.Google Scholar
  180. West, T. E., Papasian, C. J., Park, B. H., and Parker, S. W. (1985). Adenovirus type 2 encephalitis and concurrent Epstein-Barr virus infection in an adult man. Archives of Neurology 42: 815–817.Google Scholar
  181. Whitley, R. J. (1990). Viral encephalitis. New England Journal of Medicine 323: 242–250.Google Scholar
  182. Whitley, R. J., Alford, C. A., Hirsch, M. S., Schooley, R. T., Luby, J. P., Aoki, F. Y., Hanley, D., Nahmias, A. J., and Soong, S. J. (1986). Vidarabine versus acyclovir therapy in herpes simplex encephalitis. New England Journal of Medicine 314: 144–149.Google Scholar
  183. Whitley, R. J., Alford, C. A., Hirsch, M. S., Schooley, R. T., Luby, J. P., Aoki, F. Y., Hanley, D., Nahmias, A. J., and Soong, S. J. (1987). Factors indicative of outcome in a comparative trial of acyclovir and vidarabine for biopsy-proven herpes simplex encephalitis. Infection 15 Suppl 1: S3–8.Google Scholar
  184. Whitley, R. J., Soong, S. J., Dolin, R., Galasso, G. J., Ch'ien, L. T., and Alford, C. A. (1977). Adenine arabinoside therapy of biopsy-proved herpes simplex encephalitis. National Institute of Allergy and Infectious Diseases collaborative antiviral study. New England Journal of Medicine 297: 289–294.Google Scholar
  185. Whitley, R. J., Soong, S. J., Linneman, C., Jr., Liu, C., Pazin, G., and Alford, C. A. (1982). Herpes simplex encephalitis. Clinical Assessment. JAMA 247: 317–320.Google Scholar
  186. Whyte, M. K., and Ind, P. W. (1986). Effectiveness of intravenous acyclovir in immunocompetent patient with herpes zoster encephalitis. British Medical Journal 293: 1536–1537.Google Scholar
  187. Wilson, B. (1992). Recovery and compensatory strategies in head injured memory impaired people several years after insult. Journal of Neurology, Neurosurgery and Psychiatry 55: 177–180.Google Scholar
  188. Wilson, L. (1976). Viral encephalopathy mimicking functional psychosis. American Journal of Psychiatry 133: 165–170.Google Scholar
  189. Wood, M., and Anderson, M. (1988). Acute encephalitis. In Anonymous, Neurological Infections, W. B. Saunders Company, London, pp. 381–486.Google Scholar
  190. Yoneda, Y., Mori, E., Yamashita, H., and Yamadori, A. (1994). MRI volumetry of medial temporal lobe structures in amnesia following herpes simplex encephalitis. European Neurology 34: 243–252.Google Scholar
  191. Yoneda, Y., Yamadori, A., Mori, E., and Yamashita, H. (1992). Isolated prolonged retrograde amnesia. European Neurology 32: 340–342.Google Scholar
  192. Young, E. J., Killam, A. P., and Greene, J. F. (1976). Disseminated herpesvirus infection. Association with primary genital herpes in pregnancy. JAMA 235: 2731–2733.Google Scholar
  193. Yu, Y. L., Lau, Y. N., Woo, E., Wong, K. L., and Tse, B. (1988). Cryptococcal infection of the nervous system. Quarterly Journal of Medicine 66: 87–96.Google Scholar
  194. Zifroni, A., Fried, M., Shalmon, B., Hoffman, M., and Yust, I. (1997). Severe encephalitis with rapid recovery. Lancet I: 1328–1328.Google Scholar

Copyright information

© Plenum Publishing Corporation 2000

Authors and Affiliations

  • Laura Hokkanen
    • 1
  • Jyrki Launes
    • 2
  1. 1.Department of NeurologyUniversity of HelsinkiHelsinkiFinland
  2. 2.Department of NeurologyUniversity of HelsinkiHelsinkiFinland

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