Transgenic Research

, Volume 9, Issue 2, pp 145–154 | Cite as

Role of the melanocortin-4 receptor in metabolic rate and food intake in mice

  • Airu S. Chen
  • Joseph M. Metzger
  • Myrna E. Trumbauer
  • Xiao-ming Guan
  • Hong Yu
  • Easter G. Frazier
  • Donald J. Marsh
  • Michael J. Forrest
  • Shobhna Gopal-Truter
  • Jill Fisher
  • Ramon E. Camacho
  • Alison M. Strack
  • Theodore N. Mellin
  • D. Euan MacIntyre
  • Howard Y. Chen
  • Lex H.T. Van der Ploeg

Abstract

We evaluated the role of the melanocortin-4 receptor (MC-4R) in the control of metabolic rate and food intake in mice. Intraperitoneal administration of the non-selective MC-R agonist melanotan II (MT-II; a cyclic heptapeptide) increases metabolic rate in wildtype mice, while MC-4R knockout mice are insensitive to the effects of MT-II on metabolic rate. MC-4R knockout mice are also insensitive to the effects of MT-II on reducing food intake. We conclude that MC-4R can mediate control of both metabolic rate and food intake in mice. We infer that a role for MC-3R in mediating the acute effects of MT-II on basal metabolic rate and food intake in wildtype mice seems limited.

food intake melanocortin-4 receptor metabolic rate MT-II 

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Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • Airu S. Chen
    • 1
  • Joseph M. Metzger
    • 2
  • Myrna E. Trumbauer
    • 1
  • Xiao-ming Guan
    • 1
  • Hong Yu
    • 1
  • Easter G. Frazier
    • 1
  • Donald J. Marsh
    • 1
  • Michael J. Forrest
    • 2
  • Shobhna Gopal-Truter
    • 3
  • Jill Fisher
    • 3
  • Ramon E. Camacho
    • 2
  • Alison M. Strack
    • 2
  • Theodore N. Mellin
    • 2
  • D. Euan MacIntyre
    • 2
  • Howard Y. Chen
    • 2
  • Lex H.T. Van der Ploeg
    • 1
  1. 1.Department of Metabolic Disorders, Merck Research Laboratories
  2. 2.Department of Animal Pharmacology, Merck Research Laboratories
  3. 3.Department of Comparative MedicineMerck Research LaboratoriesRahway

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