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Cellulose-based hydrogels as body water retainers

  • A. Sannino
  • A. Esposito
  • L. Nicolais
  • M. A. Del Nobile
  • A. Giovane
  • C. Balestrieri
  • R. Esposito
  • M. Agresti
Article

Abstract

In this work the possibility of using hydrogels as body water retainers for a therapeutic aid in pathologies such as oedemas of various origins was explored. For such a purpose, the material requires a good compatibility and a controlled swelling capacity without altering the body electrolyte homeostasis. The hydrogel was designed to meet the swelling requirements with the physiological constraints and its biocompatibility was assessed either in vitro or in vivo. Absorption tests were performed in order to define the swelling behavior by varying the pH and ion content of the external solution. The hydrogel swelling capacity was assessed in the presence of various solvents, in order to evaluate its absorption capacity in solutions similar to biological fluids. In addition, the capacity of the gel to modify electrolyte homeostasis by adsorbing ions such as calcium, potassium and sodium was tested. In order to assess the gel biocompatibility after contact of the hydrogel with intestinal cells, arachidonic acid relase was determined. No significant intracellular increase of free arachidonic acid was found in the cells after up to 2 h of contact with the gel. The results suggest that, as far as brief periods are concerned, the gel does not cause an inflammatory response in intestinal cells. ©2000 Kluwer Academic Publishers

Keywords

Sodium Polymer Calcium Potassium Inflammatory Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • A. Sannino
    • 1
  • A. Esposito
    • 1
  • L. Nicolais
    • 1
  • M. A. Del Nobile
    • 2
  • A. Giovane
    • 3
  • C. Balestrieri
    • 3
  • R. Esposito
    • 4
  • M. Agresti
    • 5
  1. 1.Department of Materials and Production EngineeringUniversity of Naples “Federico II”NaplesItaly
  2. 2.National Research CouncilInstitute of Composite Materials TechnologyNaplesItaly
  3. 3.Department of Biochemistry and BiophysicsSecond University of NaplesNaplesItaly
  4. 4.Division of Clinical NutritionInstitute of Surgical AnatomyNaplesItaly
  5. 5.Institute of Surgical SenologyNaplesItaly

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