Cancer Causes & Control

, Volume 11, Issue 7, pp 627–633

Employment as butcher and cancer risk in a record-linkage study from Sweden

  • Paolo Boffetta
  • Gloria Gridley
  • Per Gustavsson
  • Paul Brennan
  • Aaron Blair
  • Anna Mia Ekström
  • Joseph F. Fraumeni


Objective: To investigate the risk of cancer among butchers and other meat workers in a large record-linkage study from Sweden.

Methods: The Swedish Cancer Environment Register III contains nationwide data on cancer incidence during 1971–1989 for all residents, by occupation and industry of employment as reported at the 1960 and 1970 censuses. We identified 25,049 men classified as butchers or meat workers at either census. We used as a comparison group the remaining part of the active male population, after exclusion of workers with direct contact with animals.

Results: Butchers in the meat industry had a slight increase in the risk of cancer (relative risk [RR] 1.1, 95% confidence interval [CI] 1.0–1.3), which was due to an increased risk of cancers of the oral cavity and pharynx (RR 1.6, 95% CI 1.0–2.7), stomach (RR 1.6, 95% CI 1.1–2.7), larynx (RR 1.4, 95% CI 0.6–3.4), and lung (RR 1.4, 95% CI 1.1–1.9). The risk of stomach cancer was highest during the first 5 years of the study, and among butchers from urban areas. No temporal or geographic variations were seen for lung cancer risk, with elevations restricted to squamous cell carcinoma. An increased risk of stomach, laryngeal and lung cancers was present in butchers and meat workers outside the meat industry. There was no clear indication of an increased risk of other neoplasms.

Conclusions: The increased risk of oral, laryngeal, lung and stomach cancers among Swedish butchers may be at least partly due to confounding by tobacco smoking, alcohol drinking, and other lifestyle factors. However, exposures in the meat industry (e.g., viruses, nitrosamines, polycyclic aromatic hydrocarbons) may contribute the elevated cancer risks.

butchers epidemiology lung neoplasms occupational exposures stomach neoplasms 


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  1. 1.
    Fox AJ, Lynge E, Malker H (1982) Lung cancer in butchers. Lancet 1: 165–166.Google Scholar
  2. 2.
    Coggon D, Pannett B, Pippard EC, Winter PD (1989) Lung cancer in the meat industry. Br J Ind Med 46: 188–191.Google Scholar
  3. 3.
    Reif JS, Pearce NE, Fraser J (1989) Cancer risks among New Zealand meat workers. Scand J Work Environ Health 15: 24–29.Google Scholar
  4. 4.
    Guberan E, Usel M, Raymond L, Fioretta G (1993) Mortality and incidence of cancer among a cohort of self employed butchers from Geneva and their wives. Br J Ind Med 50: 1008–1016.Google Scholar
  5. 5.
    Johnson ES (1994) Cancer mortality among workers in the meat department of supermarkets. Occup Environ Med 51: 541–547.Google Scholar
  6. 6.
    Johnson ES, Dalmas D, Noss J, Matanoski GM (1995) Cancer mortality among workers in abattoirs and meatpacking plants: an update. Am J Ind Med 27: 389–403.Google Scholar
  7. 7.
    Pearce NE, Smith AH, Howard JK, Sheppard RA, Giles HJ, Teague CA (1986) Non-Hodgkinĩs lymphoma and exposure to phenoxyherbicides, chlorophenols, fencing work, and meat works employment: a case-control study. Br J Ind Med 43: 75–83.Google Scholar
  8. 8.
    Pearce NE, Sheppard RA, Smith AH, Teague CA (1987) Non-Hodgkin's lymphoma and farming: an expanded case-control study. Int J Cancer 39: 155–161.Google Scholar
  9. 9.
    Pearce NE, Smith AH, Reif JS (1988) Increased risks of soft tissue sarcoma, malignant lymphoma, and acute myeloid leukemia in abattoir workers. Am J Ind Med 14: 63–72.Google Scholar
  10. 10.
    Metayer C, Johnson ES, Rice JC (1998) Nested case-control study of tumors of the hemopoietic and lymphatic systems among workers in the meat industry. Am J Epidemiol 147: 727–738.Google Scholar
  11. 11.
    Vena JE, Byers T, Swanson M, Cookfair D (1982) Lung cancer in butchers? Lancet 2: 713.Google Scholar
  12. 12.
    Milham S (1982) Lung cancer in butchers. Lancet 1: 690.Google Scholar
  13. 13.
    Coggon D, Wield G (1995) Mortality of butchers and cooks identified from the 1961 census of England and Wales. Occup Environ Med 52: 157–159.Google Scholar
  14. 14.
    Johnson ES, Shorter C, Rider B, Jiles R (1997) Mortality from cancer and other diseases in poultry slaughtering/processing plants. Int J Epidemiol 26: 1142–1150.Google Scholar
  15. 15.
    Gustavsson P, Fellenius E, Hogstedt C (1987) Possible causes of increased lung cancer incidence among butchers and slaughterhouse workers. Scand J Work Environ Health 13: 518–523.Google Scholar
  16. 16.
    Nordholm L, Espensen IM, Jensen HS, Holst E (1986) Polycyclic aromatic hydrocarbons in smokehouses. Scand J Work Environ Health 12: 614–618Google Scholar
  17. 17.
    National Central Bureau of Statistics (1975) Census of the Population in 1970. Stockholm: National Central Bureau of Statistics.Google Scholar
  18. 18.
    Breslow NE, Day NE (1987) Statistical Methods in Cancer Research, Vol. II: The Design and Analysis of Cohort Studies (IARC Sci. Publ. No. 82). Lyon: International Agency for Research on Cancer.Google Scholar
  19. 19.
    Milham S (1976) Occupational Mortality in Washington State 1950–1971. Cincinnati, OH: US Department of Health, Education and Welfare, National Institute of Occupational Safety and Health.Google Scholar
  20. 20.
    Schoenberg JB, Stemhagen A, Mason TJ, Patterson J, Bill J, Altman R (1987) Occupation and lung cancer among New Jersey white males. J Natl Cancer Inst 79: 13–21.Google Scholar
  21. 21.
    Ronco G, Ciccone G, Mirabelli D, Troia B, Vineis P (1988) Occupation and lung cancer in two industrialized areas of northern Italy. Int J Cancer 41: 354–358.Google Scholar
  22. 22.
    Gallagher RP, Threlfall WJ, Band PR, Spinelli JJ (1989) Occupational Mortality in British Columbia 1950–1984. Vancouver, BC: Cancer Control Agency of British Columbia.Google Scholar
  23. 23.
    Costa G, Faggiano F, Lagorio S (1995) Occupational Mortality in Italy in the 1980s [in Italian]. Rome: Instituto Superiore per la Prevenzione e la Sicurezza del Lavoro.Google Scholar
  24. 24.
    Pukkala E (1995) Cancer Risk by Social Class and Occupation: a Survey of 109,000 Cancer Cases among Finns of Working Age. Berlin: Springer.Google Scholar
  25. 25.
    Johnson ES (1991) Nested case-control study of lung cancer in the meat industry. J Natl Cancer Inst 83: 1337–1339.Google Scholar
  26. 26.
    Jockel KH, Ahrens W, Jahn I, Pohlabeln H, Bolm-Audor. U (1998) Occupational risk factors for lung cancer: a case-control study in West Germany. Int J Epidemiol 27: 549–560.Google Scholar
  27. 27.
    Benton EC (1994) Warts in butchers-a cause for concern? Lancet 343: 1114.Google Scholar
  28. 28.
    Al-Ghamdi AA, Sanders CM, Keefe M, Coggon D, Maitland NJ (1995) Human papilloma virus DNA and TP53 mutations in lung cancers from butchers. Br J Cancer 72: 293–297.Google Scholar
  29. 29.
    Hrubec Z, Blair AE, Vaught J (1995) Mortality Risks by Industry among U.S. Veterans of Known Smoking Status (NIH Publ. No. 95–2747). Washington, DC: US Department of Health and Human Services.Google Scholar
  30. 30.
    Dubrow R, Wegman DH (1984) Cancer and occupation in Massachusetts: a death certificate study. Am J Ind Med 6: 207–230.Google Scholar
  31. 31.
    Olsen JH, Jensen OM (1987) Occupation and risk of cancer in Denmark: an analysis of 93,810 cancer cases, 1970–1979. Scand J Work Environ Health 13(Suppl. 1): 1–91.Google Scholar
  32. 32.
    Forman D (1987) Dietary exposure to N-nitroso compounds and the risk of human cancer. Cancer Surv 6: 719–738.Google Scholar
  33. 33.
    Husson MO, Vincent P, Grabiaud MH, Furon D, Leclerc H (1991) Anti-Helicobacter pylori IgG levels in abattoir workers. Gastroenterol Clin Biol 15: 723–726.Google Scholar
  34. 34.
    Vaira D, D'Anastasio C, Holton J, et al. Campylobacter pylori in abattoir workers: is it a zoonisis? Lancet 2: 725–726.Google Scholar
  35. 35.
    Morris A, Nicholson G, Lloyd G, Haines D, Rogers A, Taylor D (1986) Seroepidemiology of Campylobacter pyloridis. NZ Med J 99: 657–659.Google Scholar
  36. 36.
    Fox JG (1995) Non-human reservoirs of Helicobacter pylori. Aliment Pharmacol Ther 9(Suppl. 2): 93–103.Google Scholar
  37. 37.
    Rocha GA, Queiroz DM, Mendes EN, Oliveira AM, Moura SB, Silva RJ (1992) Source of Helicobacter pylori infection: studies in abattoir workers and pigs. Am J Gastroenterol 87: 1525.Google Scholar
  38. 38.
    Bohmler G, Gerwert J, Scupin E, Sinell HJ (1996) The epidemiology of helicobacteriosis in humans; studies of the survival capacity of the microbe in food [in German]. Dtsch Tierarztl Wochenschr 103: 438–443.Google Scholar
  39. 39.
    Franceschi S, Serraino D, La Vecchia C, Bidoli E, Tirelli U (1991) Occupation and risk of Hodgkin's disease in North-East Italy. Int J Cancer 48: 831–835.Google Scholar
  40. 40.
    Loomis DP, Savitz DA (1991) Occupation and leukemia mortality among men in 16 States: 1985–1987. Am J Ind Med 19: 509–521.Google Scholar
  41. 41.
    Warnryd B, Ostlin P, Thorslund M (1989) Living Conditions. Appendix 11. Quality in retrospective questions on previous occupational exposures: an evaluation of occupational histories in the investigation on living conditions [in Swedish]. Stockholm: Statistics Sweden, 1989.Google Scholar
  42. 42.
    National Central Bureau of Statistics (1965) Smoking Habits in Sweden: A Mail Survey-Spring 1963. Stockholm: National Central Bureau of Statistics.Google Scholar
  43. 43.
    Carstensen JM, Pershagen G, Eklung G (1988) Smoking-adjusted incidence of lung cancer among Swedish men in different occupations. Int J Epidemiol 17: 753–758.Google Scholar
  44. 44.
    Hogstedt C, Carstensen J, Svensson E, Weiner J (1983) Respiratory cancer in butchers and bakers [in Swedish]. Abstract presented at the annual meeting of the Swedish Society of Medicine.Google Scholar
  45. 45.
    Hemmingsson T, Lundberg I, Romelsjo A, Alfredsson L (1997) Alcoholism in social classes and occupations in Sweden. Int J Epidemiol 26: 584–591.Google Scholar

Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • Paolo Boffetta
    • 1
    • 2
  • Gloria Gridley
    • 1
  • Per Gustavsson
    • 3
  • Paul Brennan
    • 2
  • Aaron Blair
    • 1
  • Anna Mia Ekström
    • 4
  • Joseph F. Fraumeni
    • 1
  1. 1.Division of Cancer Epidemiology and GeneticsNational Cancer InstituteBethesdaUSA
  2. 2.Unit of Environmental Cancer EpidemiologyInternational Agency for Research on CancerLyonFrance
  3. 3.Department of Occupational HealthKarolinska HospitalStockholmSweden
  4. 4.Department of Medical EpidemiologyKarolinska InstituteStockholmSweden

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