Calcium phosphate bone cements for clinical applications. Part I: Solution chemistry

  • E. Ferna´ndez
  • F. J. Gil
  • M. P. Ginebra
  • F. C. M. Driessens
  • J. A. Planell
  • S. M. Best


Calcium phosphate cements have been the subject of many studies in the last decade because of their biocompatibility, their capacity to fill bone cavities and their hardening properties; properties which are desirable in a broad range of surgical applications. The setting and hardening of these materials are controlled by dissolution–precipitation chemical reactions at room or body temperature and involve crystalline phase transformations. © 1999 Kluwer Academic Publishers


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    D. F. Williams and R. Roaf,“Implants in surgery” (W. B. Saunders Company Ltd., London, 1973).Google Scholar
  2. 2.
    FifthWorld Biomaterials Congress, “Program and Transactions”, Volumes 1 and 2, Toronto (Canada), May 29-June 2 (1996).Google Scholar
  3. 3.
    K. De Groot, “Bioceramics of calcium phosphate” (CRC Press, Boca Raton, 1983).Google Scholar
  4. 4.
    F. C. M. Driessens and R. M. H. Verbeeck, “Biominerals” (CRC Press, Boca Raton, 1990).Google Scholar
  5. 5.
    I. N. Levine, “FisicoquiÂmica”, 3th edition (McGraw-Hill, Madrid, 1981).Google Scholar
  6. 6.
    M. Hein, L. R. Best, S. Pattison and S. Arena,“College chemistry: an introduction to general, organic and biochemistry”, 5th edition (Brooks/Cole Publishing Company, Paci®c Grove, California, 1993).Google Scholar
  7. 7.
    L. C. Chow, J. Ceram. Soc. Japan Int. Edn. 99 (1992) 927.Google Scholar
  8. 8.
    N. S. Mandel, Arthritis Rheum. 19 (1976) 439.PubMedGoogle Scholar
  9. 9.
    J. R. Van Wazer, “Phosphorous and its compounds”, Vol. I. Chemistry (Interscience Publisher Inc., New York, 1958).Google Scholar
  10. 10.
    W. E. Brown and L. C. Chow, in “Cements Research Progress”, edited by P. W. Brown. (American Ceramic Society, Westerville, Ohio, 1986) p. 351.Google Scholar
  11. 11.
    W. E. Brown, “Environmental Phosphorous Handbook” (John Wiley & Sons, Chichester, 1973) Chap. 10, p. 203.Google Scholar
  12. 12.
    E. FernaÂndez, PhD Thesis, Universitat Politecnica de Catalunya (1996).Google Scholar
  13. 13.
    G. Vereecke and J. Lemaitre, J. Cryst. Growth 104 (1990) 820.Google Scholar
  14. 14.
    R. Boistelle and I. LoÂPez-valero, J. Cryst. Growth 102 (1990) 609.Google Scholar
  15. 15.
    F. Abbona and M. Franchini-angela, J. Cryst. Growth 104 (1990) 661.Google Scholar
  16. 16.
    M. R. Christoffersen, J. Christoffersen and W. Kibalczyc, J. Cryst. Growth 106 (1990) 349.Google Scholar
  17. 17.
    E. FernaÂndez, M. G. Boltong, M. P. Ginebra, O. Bermu  dez, F. C. M. Dries sens and J. A. Planell, Clin. Mater. 16 (1994) 99.Google Scholar
  18. 18.
    J. Lemaitre, Innov. Tech. Biol. Med. 16 (1995) 109.Google Scholar
  19. 19.
    F. C. M. Driessens, in “Engineering ceramics”, Euroceramics 3, edited by G de With, R.A. Terpstra and R. Metselaar, Elsevier, London, (1989) p. 3.48.Google Scholar
  20. 20.
    F. C. M. Driessens and R. M. H. Verbeeck, in “Implant materials in biofunction” edited by C. de Putter, G.L. de Lange, K. de Groot. Elsevier, Amsterdam, (1988) p. 105.Google Scholar
  21. 21.
    F. C. M. Dries sens, Ann. NY. Acad. Sci. 523 (1988) 131.PubMedGoogle Scholar
  22. 22.
    F. C. M. Driessens, M. M. A. Ramselaar, H. U. Schaeken, A. L. H. Stols and P. J. Van Mullem, J. Mater. Sci. Mater Med. 3 (1992) 413.Google Scholar
  23. 23.
    M. M. A. Ramselaar, F. C. M. Driessens, W. Kalk, J. R. De Wyn and P. J. Van Mullem,J. Mater. Sci. Mater Med. 2 (1991) 63.Google Scholar
  24. 24.
    W. E. Brown and L. C. Chow, US Patent 4 518, 430, May 21, 1985.Google Scholar
  25. 25.
    W. E. Brown and L. C. Chow, US Patent 4 612, 053, Sept. 16, 1986.Google Scholar
  26. 26.
    B. R. Constantz, US Patent 4 880, 610, Nov. 14, 1989.Google Scholar
  27. 27.
    W. E. Brown and L. C. Chow, European Patent EP 0-416-761-A1, Aug. 13, 1990.Google Scholar
  28. 28.
    B. R. Constantz, B. Barr and K. Mcvicker, US Patent 5 053, 212, Oct. 1, 1991.Google Scholar
  29. 29.
    S. T. Liu and H. H. Chung, US Patent 5 149, 368, Sept. 22, 1992.Google Scholar
  30. 30.
    M. Hirano and H. Takeuchi, US Patent 5 152, 836, Oct. 6, 1992.Google Scholar
  31. 31.
    M. G. Boltong, Spanish Patent P 9102606, April 7, 1994.Google Scholar
  32. 32.
    M. Bohner and J. Lemaitre, Swiss Patent Appl. No 2730/ 93-9, Sept. 20, 1993.Google Scholar
  33. 33.
    F. C. M. Dri essens, M. G. Boltong, E. FernaÂndez, M. P. Ginebra, F. J. Gil and J. A. Planell, Spanish Patent ES P9402604, 14-12-1995.Google Scholar
  34. 34.
    J. L. Lacout and E. Mejdoubi, French Patent FR 92.09019/ PCT/FR (1995).Google Scholar

Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • E. Ferna´ndez
    • 1
  • F. J. Gil
    • 1
  • M. P. Ginebra
    • 1
  • F. C. M. Driessens
    • 1
  • J. A. Planell
    • 1
  • S. M. Best
    • 2
  1. 1.Dpt Materials Science and MetallurgyUniversitat Polite`cnica de CatalunyaBarcelonaSpain
  2. 2.IRC in Biomedical Materials, Queen Mary and Westfield CollegeUniversity of LondonLondonUK

Personalised recommendations