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Journal of Computational Neuroscience

, Volume 9, Issue 1, pp 31–47 | Cite as

Comparison of Alternative Designs for Reducing Complex Neurons to Equivalent Cables

  • R.E. Burke
Article

Abstract

Reduction of the morphological complexity of actual neurons into accurate, computationally efficient surrogate models is an important problem in computational neuroscience. The present work explores the use of two morphoelectrotonic transformations, somatofugal voltage attenuation (AT cables) and signal propagation delay (DL cables), as bases for construction of electrotonically equivalent cable models of neurons. In theory, the AT and DL cables should provide more accurate lumping of membrane regions that have the same transmembrane potential than the familiar equivalent cables that are based only on somatofugal electrotonic distance (LM cables). In practice, AT and DL cables indeed provided more accurate simulations of the somatic transient responses produced by fully branched neuron models than LM cables. This was the case in the presence of a somatic shunt as well as when membrane resistivity was uniform.

electrotonic models voltage transients attenuation voltage propagation delay 

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Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • R.E. Burke
    • 1
  1. 1.Laboratory of Neural Control, National Institute of Neurological Disorders and StrokeNational Institutes of HealthBethesda

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