Cancer Causes & Control

, Volume 11, Issue 5, pp 459–466

Calcium, vitamin D, sunshine exposure, dairy products and colon cancer risk (United States)

  • Ellen Kampman
  • Martha L. Slattery
  • Bette Caan
  • John D. Potter
Article

Abstract

Objective: Epidemiologic studies on calcium, vitamin D and colon cancer are inconsistent, whereas experimental studies more regularly show a protective effect. To evaluate potential sources of inconsistencies, data from a large case–control study were analyzed, stratifying on potential effect modifiers.

Methods: Data were collected by certified interviewers in Northern California, Utah and Minnesota. Analyses included 1993 incident colon cancer cases and 2410 population-based controls. Multivariate logistic regression models included age, sex, BMI, family history, physical activity, intake of energy, dietary fiber, aspirin and NSAIDs.

Results: Dietary calcium was inversely associated with colon cancer risk in men (OR highest vs lowest quintile = 0.6, 95% CI = 0.5–0.9) and women (OR = 0.6, 95% CI = 0.4–0.9). No statistically significant associations were observed for dietary vitamin D or sunshine exposure. Consumption of total low-fat dairy products was associated with a statistically significantly decreased risk in men and women (ORs highest vs lowest category of intake = 0.8 and 0.7 respectively). Calcium supplement use was inversely associated with risk in both sexes (ORs use vs non-use = 0.8). Vitamin D supplements were inversely associated with risk in men (OR = 0.5) and women (OR = 0.6) but confidence limits included 1.0.

Conclusions: These data provide additional support of an inverse association between high levels of calcium intake and colon cancer risk.

calcium colon cancer effect modification vitamin D 

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Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • Ellen Kampman
    • 1
  • Martha L. Slattery
    • 3
  • Bette Caan
    • 4
  • John D. Potter
    • 1
  1. 1.Cancer Prevention Research ProgramFred Hutchinson Cancer Research CenterSeattleUSA
  2. 2.Wageningen UniversityUSA
  3. 3.University of Utah Medical SchoolSalt Lake CityUSA
  4. 4.Kaiser Permanente Medical Research ProgramOaklandUSA

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