Biotechnology Techniques

, Volume 13, Issue 1, pp 37–42 | Cite as

Model based calculation of substrate/inducer feed-rate profiles in fed-batch processes for recombinant protein production

  • D. Levisauskas
  • V. Galvanauskas
  • R. Simutis
  • A. Lübbert


A model-based feed-rate profile optimization problem is discussed for the fed-batch recombinant protein production. Two optimization procedures, an evolutionary programming technique and a simplified method using the dynamic programming concept, are discussed and compared. Modeling as well as experimental results are presented.

fed-batch cultivation recombinant protein E. coli model based optimization 


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Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • D. Levisauskas
    • 1
  • V. Galvanauskas
    • 1
  • R. Simutis
    • 1
  • A. Lübbert
    • 2
  1. 1.Process Control DepartmentKaunas University of TechnologyKaunasLithuania
  2. 2.Institut für BioverfahrenstechnikMartin-Luther-Universität Halle-WittenbergHalle (Saale)Germany

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