Quality of Life Research

, Volume 7, Issue 1, pp 39–55 | Cite as

A questionnaire to assess the generic and disease-specific health outcomes of patients with chronic hepatitis C

  • Martha S. Bayliss
  • Barbara Gandek
  • Kathleen M. Bungay
  • David Sugano
  • Ming-Ann Hsu
  • John E. WareJr


A 69-item questionnaire measuring generic functioning and well-being and disease-specific health outcomes was developed and tested using the pre-treatment data from patients with chronic hepatitis C (CHC) participating in two randomized trials of interferon α-2b (n = 157). The questionnaire included all eight scales from the SF-36 and measures of nine other generic and disease-specific health concepts. Psychometric tests confirmed the assumptions underlying the construction and scoring of all generic and disease-specific scales. Cross-sectional tests of ‘known groups’ validity showed that CHC patients scored worse on the generic scales than patients with other chronic conditions and worse than a healthy general population. The generic and disease-specific scale scores were lower in the presence of physical findings of CHC, as hypothesized, but only the physical functioning and bodily pain scales were linked to cirrhosis or extreme alanine aminotransferase (ALT) ratios. This instrument will be useful in studies of health outcome among patients with CHC, a condition whose health burden appears to have been underestimated in studies to date.

Health status SF-36 Health Survey hepatitis C questionnaire 


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Copyright information

© Chapman and Hall 1997

Authors and Affiliations

  • Martha S. Bayliss
    • 1
  • Barbara Gandek
    • 1
  • Kathleen M. Bungay
    • 1
  • David Sugano
    • 2
  • Ming-Ann Hsu
    • 1
  • John E. WareJr
    • 3
  1. 1.The Health Institute, New England Medical CenterBostonUSA
  2. 2.USA Schering-Plough Inc Pfizer Inc.USA
  3. 3.Tufts University School of Medicine USA and Harvard School of Public HealthUSA

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