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Journal of Computational Neuroscience

, Volume 6, Issue 2, pp 145–168 | Cite as

An Improved Parameter Estimation Method for Hodgkin-Huxley Models

  • Allan R. Willms
  • Deborah J. Baro
  • Ronald M. Harris-Warrick
  • John Guckenheimer
Article

Abstract

We consider whole-cell voltage-clamp data of isolated currents characterized by the Hodgkin-Huxley paradigm. We examine the errors associated with the typical parameter estimation method for these data and show them to be unsatisfactorally large especially if the time constants of activation and inactivation are not sufficiently separated. The size of these errors is due to the fact that the steady-state and kinetic properties of the current are estimated disjointly. We present an improved parameter estimation method that utilizes all of the information in the voltage-clamp conductance data to estimate steady-state and kinetic properties simultaneously and illustrate its success compared to the standard method using simulated data and data from P. interruptus shal channels expressed in oocytes.

Hodgkin-Huxley models parameter estimation voltage clamp least squares 

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Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • Allan R. Willms
    • 1
  • Deborah J. Baro
    • 2
  • Ronald M. Harris-Warrick
    • 2
  • John Guckenheimer
    • 3
  1. 1.Biomathematics Research Centre, Department of Mathematics and StatisticsUniversity of CanterburyChristchurchNew Zealand
  2. 2.Section of Neurobiology and BehaviorCornell UniversityIthaca
  3. 3.Department of Mathematics and Center for Applied MathematicsCornell UniversityIthaca

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