Cancer Causes & Control

, Volume 9, Issue 4, pp 381–387

Cancer mortality among Moscow shoe workers exposed to chloroprene (Russia)

  • Mariana A. Bulbulyan
  • Oxana V. Changuina
  • David G. Zaridze
  • Sergey V. Astashevsky
  • Didier Colin
  • Paolo Boffetta
Article

Abstract

Objectives: To assess the risk of cancer among workers of a Moscow (Russia) shoe factory exposed to chloroprene (2-chloro-1,3-butadiene) (CP).

Methods: This is a retrospective cohort mortality study among 5,185 shoe manufacturing workers employed between 1940 and 1976, and followed from 1979 through 1993. Exposure to CP was assessed by linking the job history with industrial hygiene data. We calculated standardized mortality ratios (SMR) using the Moscow population as reference, and conducted an internal comparison analysis based on Poisson regression modeling.

Results: For the entire cohort, all-cause mortality was close to expectation and all-cancer mortality was increased. There was an increase in the mortality from liver cancer (SMR=2.4, 95 percent confidence interval [CI]=1.1-4.3), kidney cancer (SMR=1.8, CI=0.9-3.4), and leukemia (SMR=1.9, CI=1.0-3.3). Mortality from liver cancer and leukemia was associated with various indicators of CP exposure. A similar, although less consistent, pattern was found for kidney cancer mortality; while for the remaining neoplasms, no association was suggested with CP exposure.

Conclusions: The association between CP exposure and risk of leukemia may be due to concomitant exposure to benzene. The results for liver cancer point towards a carcinogenic effect of CP.

Cancer mortality chloroprene Russia shoe workers 

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References

  1. 1.
    International Agency for Research on Cancer. Boot and Shoe Manufacture and Repair. Lyon, France: IARC, 1987; IARC Monogr Eval Carcinog Risk Chem Humans, Suppl. 7, Overall Evaluations of Carcinogenicity; an Updating of IARC Monographs Volumes 1–42: 232–5.Google Scholar
  2. 2.
    International Agency for Research on Cancer. Chloroprene and Polychloroprene. Lyon, France: IARC, 1979; IARC Monogr Eval Carcinog Risk Chem Humans, Vol. 19, Some Monomers, Plastics and Synthetic Elastomers, and Acrolein: 131–56.Google Scholar
  3. 3.
    Culik R, Kelly DP, Clary JJ. Inhalation studies to evaluate the teratogenic and embriotoxic potential of b-chloroprene (2-chlorobutadiene-1,3). Toxic Appl Pharmacol 1978; 44: 81–8.Google Scholar
  4. 4.
    Shelby MD. Results of NTP-sponsored mouse cytogenetic studies on 1,3-butadiene, isoprene, and chloroprene. Envir Health Perspec 1990; 86: 71–3.Google Scholar
  5. 5.
    Zilfjan VN, Fichidzhyan BS, Pogosova AM. Results of testing chloroprene for carcinogenicity [in Russian]. Acad Sci Armen SSR, Zh eksp klin Med 1975; 15: 54–7.Google Scholar
  6. 6.
    Pell S. Mortality of workers exposed to chloroprene. J Occup Med 1978; 20: 21–9.Google Scholar
  7. 7.
    Li S, Dong Q, Yuqing L, Yingfei L. Epidemiologic study of cancer mortality among chloroprene workers. Biom Environ Sci 1989; 2: 141–9.Google Scholar
  8. 8.
    Bulbulyan MA, Uloyan SM, Margaryan AG, Astashevsky S. Risk of liver cancer in workers exposed to chloroprene [Abstract]. Proceedings of the 11thInternational Symposium on Epidemiology in Occupational Health, The Netherlands, 5-8 September 1995. Epidemiology 1995; 6: S133.Google Scholar
  9. 9.
    Word Health Organization. International Classification of Diseases, Ninth Revision. Geneva, Switzerland: WHO, 1978.Google Scholar
  10. 10.
    Volkova ZA, Fedotova MI, Choang BC. Ozdorovlenie uslovii truda na Moscow obuvnich fabrikach [in Russian]. In: Aldireva MV, Djakova GA, Babina MD, Ponomareva AA, eds. Gigiena Truda na Predprijatijach Moskvi. Medicina 1974: 106–11.Google Scholar
  11. 11.
    Breslow NE, Day NE. Statistical Methods in Cancer Research. Vol II. The Design and Analysis of Cohort Studies. Lyon, France: International Agency for Research on Cancer, 1987; IARC Sci. Pub. No. 82.Google Scholar
  12. 12.
    Mantel N, Haenzel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959; 22: 719–48.Google Scholar
  13. 13.
    Stata. Stata Statistical Software: Release 5.0. College Station, TX (USA): Stata Corporation, 1997.Google Scholar
  14. 14.
    Bulbulyan M, Zahm SH, Zaridze DG. Occupational cancer mortality among urban women in the former USSR. Cancer Causes Control 1992; 3: 299–307.Google Scholar
  15. 15.
    London WT, McGlynn KA. Liver cancer. In: Schottenfeld D, Fraumeni JF Jr, eds. Cancer Epidemiology and Prevention. Second Edition. New York, NY (USA): Oxford University Press, 1996: 772–93.Google Scholar
  16. 16.
    Herbert JT. Angiosarcoma of the Liver in a Rubber Worker. Atlanta, GA (USA): Centers for Disease Control and Prevention, 1976; (Angiosarcoma surveillance memorandum).Google Scholar
  17. 17.
    Englund A. Cancer incidence among painters and some allied trades. J Toxicol Environ Health 1980; 6: 1267–73.Google Scholar
  18. 18.
    Decoufle P, Walrath J. Proportionate mortality among US shoeworkers, 1966–1977. Am J Ind Med 1983; 4: 523–32.Google Scholar
  19. 19.
    International Agency for Research on Cancer. Benzene. In: Some Industrial Chemical and Dyestuffs. Lyon, France: IARC, 1982; IARC Monogr Eval Carcinog Risk Chem Humans, Vol. 29: 93–148.Google Scholar
  20. 20.
    Aksoy M, Erdem S, DinCol G. Leukemia in shoe workers exposed chronically to benzene. Blood 1974; 44: 837–41.Google Scholar
  21. 21.
    Vigliani EC. Leukemia associated with benzene exposure. Ann NY Acad Sci 1976; 271: 143–51.Google Scholar
  22. 22.
    Malker HR, Malker BK, McLaughlin JK. Kidney cancer among leather workers. Lancet 1984; i: 56.Google Scholar
  23. 23.
    Walker JT, Bloom TF, Stern FB, Okun AH, Fingerhut MA, Halperin WE. Mortality of workers employed in shoe manufacturing. Scand J Work Environ Health 1993; 19: 89–95.Google Scholar
  24. 24.
    Fu H, Demers PA, Constantini AS, et al. Cancer mortality among shoe manufacturing workers: an analysis of two cohorts. Occup Environ Med 1996; 53: 394–8.Google Scholar
  25. 25.
    Berg MT, Burke CA, Chen JL, Walrath J, Pell S, Gallie CR. Cancer incidence and mortality in the du Pont Company: an update. J Occup Med 1987; 20: 245–52.Google Scholar
  26. 26.
    Anderson KE, Potter JD, Mack TM. Pancreatic cancer. In: Schottenfeld D, Fraumeni JF Jr, eds. Cancer Epidemiology and Prevention. Second Edition. New York, NY (USA): Oxford University Press, 1996: 725–71.Google Scholar
  27. 27.
    Pietri F, Clavel F. Occupational exposure and cancer of the pancreas: a review. Br J Ind Med 1991; 48: 583–7.Google Scholar
  28. 28.
    Waxweiler RJ, Stringer W, Wagoner JK, Jones J. Neoplastic risk among workers exposed to vinyl chloride. Ann NY Acad Sci 1976; 271: 40–8.Google Scholar
  29. 29.
    La Vecchia C, Levi F, Lucchini F, Negri E, Boyle P. Trends in cancer mortality in the USSR, 1965–1990. Int J Cancer 1994; 56: 31–9.Google Scholar

Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • Mariana A. Bulbulyan
    • 1
  • Oxana V. Changuina
    • 1
  • David G. Zaridze
    • 1
  • Sergey V. Astashevsky
    • 1
  • Didier Colin
    • 2
  • Paolo Boffetta
    • 2
  1. 1.Department of Epidemiology and PreventionInstitute of Carcinogenesis, RAMS Cancer Research CentreMoscowRussia
  2. 2.International Agency for Research on CancerUnit of Environmental Cancer EpidemiologyFrance

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