Cancer Causes & Control

, Volume 9, Issue 5, pp 487–509 | Cite as

Physical activity and cancer etiology: associations and mechanisms

  • Anne McTiernan
  • Cornelia Ulrich
  • Shelley Slate
  • John Potter


Objectives: This paper reviews the epidemiologic data of associations between physical activity and cancer risk, describes potential mechanisms for a physical activity cancer link, and proposes future directions for research. Methods: We reviewed English-language published papers on physical activity and cancer through Medline searches for epidemiologic studies, and through references on individual reports. We reviewed general texts on effects of exercise on human biology and applied the concepts to the biology of cancer in humans to describe potential mechanisms for a physical activity–cancer association.

Results: Considerable epidemiologic evidence has accrued linking increased physical activity with reduced occurrence of cancers of the breast and colon. The association between physical activity and cancers of other sites is unclear. Potential mechanisms for the association between physical activity and reduced risk for breast and colon cancer are varied: they range from bias due to physical activity's strong correlations with other health factors (e.g., diet, smoking, alcohol use, use of medications) to the metabolic effects resulting from increased physical activity and fitness, such as reduced obesity, hormonal and reproductive effects, mechanical effects, and enhancement of the immune system.

Conclusions: The elucidation of biologic mechanisms for an association between physical activity and cancer may provide biological support for the association. It will contribute information to determine the type, frequency, and duration of exercise needed to maximize protection. This information will be needed before large-scale community interventions are begun, in order to choose the correct interventions for the desired effect of reduced incidence of the most common cancers.

Cancer hormones immune function obesity physical activity 


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Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • Anne McTiernan
    • 1
    • 2
  • Cornelia Ulrich
    • 1
    • 2
  • Shelley Slate
    • 1
    • 2
  • John Potter
    • 1
    • 2
  1. 1.Fred Hutchinson Cancer Research Center, Cancer Prevention Research ProgramSeattleUSA
  2. 2.School of Public Health and Community MedicineUniversity of WashingtonSeattleUSA

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