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Journal of Computational Neuroscience

, Volume 5, Issue 1, pp 71–90 | Cite as

A Mathematical Model of the Cerebellar-Olivary System II: Motor Adaptation Through Systematic Disruption of Climbing Fiber Equilibrium

  • Garrett T. Kenyon
  • Javier F. Medina
  • Michael D. Mauk
Article

Abstract

The implications for motor learning of the model developed in the previous article are analyzed using idealized Pavlovian eyelid conditioning trials, a simple example of cerebellar motor learning. Results suggest that changes in gr→Pkj synapses produced by a training trial disrupt equilibrium and lead to subsequent changes in the opposite direction that restore equilibrium. We show that these opposing phases would make the net plasticity at each gr→Pkj synapse proportional to the change in its activity during the training trial, as influenced by a factor that precludes plasticity when changes in activity are inconsistent. This yields an expression for the component of granule cell activity that supports learning, the across-trials consistency vector, the square of which determines the expected rate of learning. These results suggest that the equilibrium maintained by the cerebellar-olivary system must be disrupted in a specific and systematic manner to promote cerebellar-mediated motor learning.

eyelid conditioning Purkinje nictitating LTP LTD 

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Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • Garrett T. Kenyon
    • 1
  • Javier F. Medina
    • 1
  • Michael D. Mauk
    • 1
  1. 1.Department of Neurobiology and AnatomyUniversity of Texas Medical School at HoustonHouston

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