Cancer Causes & Control

, Volume 9, Issue 4, pp 417–424 | Cite as

Serum concentrations of organochlorine compounds and endometrial cancer risk (United States)

  • Susan R. Sturgeon
  • Nancy Potischman
  • Nathaniel Rothman
  • Louise A. Brinton
  • Robert N. Hoover
  • John W. Brock
  • Larry L. Needham


Objectives: Endogenous and exogenous estrogens are important in the development of endometrial cancer. Several organochlorine compounds, such as o,p′-DDT, have estrogenic properties. The objective of this case-control analysis was to examine serum concentrations of organochlorine compounds and risk of endometrial cancer.

Methods: Analyses were based on a sample of 90 endometrial cancer cases and 90 individually matched community controls from a multicenter case-control study in five geographic regions of the United States. Information on potential confounders, including menstrual and reproductive factors, cigarette smoking, diet, and weight, was obtained by interview.

Results: The adjusted relative risk of endometrial cancer in the highest quartile of exposure compared with women in the lowest quartile was 0.7 (95 percent confidence interval [CI] = 0.2-2.0) for p,p′-DDE, and 0.9 for total polychlorinated biphenyls (PCBs) (CI = 0.4-2.5).

Conclusions: These findings do not support the hypothesis that organochlorine compounds are linked to the development of endometrial cancer.

Endometrial cancer DDT PCB organochlorines United States women 


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Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • Susan R. Sturgeon
    • 1
  • Nancy Potischman
    • 1
  • Nathaniel Rothman
    • 1
  • Louise A. Brinton
    • 1
  • Robert N. Hoover
    • 1
  • John W. Brock
    • 2
  • Larry L. Needham
    • 2
  1. 1.Division of Cancer Epidemiology and GeneticsNational Cancer InstituteBethesdaUSA
  2. 2.Centers for Disease ControlNational Center for Environmental HealthAtlantaUSA

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