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Pharmacy World and Science

, Volume 22, Issue 4, pp 127–129 | Cite as

Pharmacokinetics of intraventricularly administered teicoplanin in Staphylococci ventriculitis

  • L.F.M. Beenen
  • D.J. Touw
  • T.A.M. Hekker
  • D.A.J.P. Haring
Article

Abstract

Following craniotomy for a medulloblastoma in the posterior cranial fossa, a 6‐year old girl developed a ventriculitis with coagulase negative staphylococci associated with the use of a ventriculostomy. Treatment with intravenous (iv) and intraventricular (ivt) vancomycin resulted in negative cultures of the cerebrospinal fluid, but had to be stopped because of a severe allergic skin reaction. Teicoplanin was administered iv (240 mg once daily) and ivt (10 mg once daily), resulting in high teicoplanin CSF levels that were used to model the pharmacokinetics of ivt teicoplanin in this patient. No signs of recurrent infection or adverse events occurred. It is concluded that a pharmacokinetic model can be derived from this case that can be used as prior to guide teicoplanin intraventricular therapy in other patients.

Coagulase negative Staphylococcus Intraventricular administration Pharmacokinetics Teicoplanin Therapeutic drug monitoring Vancomycin Ventriculitis 

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Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • L.F.M. Beenen
    • 1
  • D.J. Touw
    • 2
  • T.A.M. Hekker
    • 3
  • D.A.J.P. Haring
    • 4
  1. 1.Departments of NeurosurgeryUniversity Hospital Vrije UniversiteitAmsterdam
  2. 2.Departments of PharmacyUniversity Hospital Vrije UniversiteitAmsterdam
  3. 3.Departments of Medical Microbiology and Infection ControlUniversity Hospital Vrije UniversiteitAmsterdam
  4. 4.Departments of PediatricsUniversity Hospital Vrije UniversiteitAmsterdam

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