Pharmacy World and Science

, Volume 21, Issue 3, pp 144–146 | Cite as

Long‐term stability of morphine and bupivacaine mixture for spinal use

  • C.M. Essink-Tjebbes
  • D.M. Burger
  • M. Beelen
  • E.W. Wuis
  • Y.A. Hekster


From clinical studies it has been proven that morphine in combination with bupivacaine is applicable in cancer pain. The availability of a ready to use parental dosage form of morphine and bupivacaine is comfortable for health care workers. Stability of a morphine or a bupivacaine preparation or a combination of both in a PVC cassette or polypropylene syringe for spinal use is examined in several studies. Apart from one study no data on long‐term stability of morphine‐bupivacaine mixture is available. A forced degradation study and a shelf‐life study at room temperature (20‐25 °C) were started on morphine hydrochloride 0.2 mg/ml and bupivacaine hydrochloride 7.5 mg/ml in 50 ml sterilized glass bottles type II. The results of the stability study showed that this mixture was stable up to 18 months at room temperature, whereafter morphine showed a slight degradation (5 %) and bupivacaine remained stable.

BupivacaineDrug stabilityMorphine 


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Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • C.M. Essink-Tjebbes
  • D.M. Burger
  • M. Beelen
  • E.W. Wuis
  • Y.A. Hekster

There are no affiliations available

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