Pharmacy World and Science

, Volume 20, Issue 3, pp 93–99 | Cite as

Measurement of patient compliance.

  • Jos F.M. Smits
  • Robert C.J.J. Passier
  • Mat J.A.P Daemen


Recent developments in our knowledge of the renin‐angiotensin system (RAS) necessitate an update of the classical view on this system. These developments pertain to the pathways leading to formation of angiotensin II and other active metabolites, their receptors, biological functions and the presence of renin‐angiotensin systems in tissues. The implications of the above new developments for the current interest in tissue renin‐angiotensin systems as potential targets for drug therapy in cardiovascular disease are discussed in this review.

ACE inhibitors Angiotensins Biological actions Biosynthesis Recptors Review Tissue renin Angiotensin systems 


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Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • Jos F.M. Smits
    • 1
  • Robert C.J.J. Passier
    • 1
  • Mat J.A.P Daemen
    • 1
  1. 1.Departments of Pharmacology and Pathology, Cardiovascular Research Institute Maastricht (CARIM)Universiteit MaastrichtThe Netherlands

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