Pharmacy World and Science

, Volume 21, Issue 2, pp 91–95 | Cite as

Flurbiprofen, S(+), eyedrops: formulation, enantiomeric assay, shelflife and pharmacology

  • Adriaan A. van Sorge
  • Peter H. Wijnen
  • Jan L. van Delft
  • Valérie M.W. Carballosa Coré‐Bodelier
  • Nicolaas J. van Haeringen


Aphakic cystoid macula edema, occurring after cataract extraction is ascribed to trauma-induced production of intra‐ocular prostaglandins. Sufficient experimental and clinical evidence supports the use of prostaglandin synthesis inhibitors to countervail this clinical condition. The active S(+)-enantiomer of flurbiprofen, a prostaglandin synthesis inhibitor, has been formulated into a stereoselective, ballast free eyedrop solution in a concentration of 0.015%. Analysis by capillary zone electrophoresis shows shelflife stability up to four years at room temperature of this enantiomer. The inhibitory effect on the synthesis of prostaglandins as measured on a homogenate of bovine iris/ciliary body, remained unaffected during a shelflife period of three years.

COX‐1 Enantiomer Eyedrops Flurbiprofen Indomethacin Prostaglandins 


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Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • Adriaan A. van Sorge
  • Peter H. Wijnen
  • Jan L. van Delft
  • Valérie M.W. Carballosa Coré‐Bodelier
  • Nicolaas J. van Haeringen

There are no affiliations available

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