Journal of Biomolecular NMR

, Volume 17, Issue 4, pp 283–294 | Cite as

DipoCoup: A versatile program for 3D-structure homology comparison based on residual dipolar couplings and pseudocontact shifts

  • Jens Meiler
  • Wolfgang Peti
  • Christian Griesinger


A program, DipoCoup, is presented that allows to search the protein data bank for proteins which have a three dimensional fold that is at least partially homologous to a protein under investigation. The three dimensional homology search uses secondary structure alignment based on chemical shifts and dipolar couplings or pseudocontact shifts for the three dimensional orientation of secondary structure elements. Moreover, the program offers additional tools for handling and analyzing dipolar couplings.

bioinformatics dipolar couplings postgenomic research protein data base structure elucidation three dimensional homology search 


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Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • Jens Meiler
    • 1
  • Wolfgang Peti
    • 1
  • Christian Griesinger
    • 1
  1. 1.Institut für Organische ChemieUniversität FrankfurtFrankfurt am Main

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