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Serum and liver lipids in rats fed diets containing corn oil, cottonseed oil, or a mixture of corn and cottonseed oils

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Abstract

Previous research has demonstrated that the total replacement of corn oil (CO) with cottonseed oil (CSO) in the diets of growing male rats results in a lowering of the total cholesterol (TC) concentration in the serum. It is not, however, known if a partial replacement of dietary CO with CSO would be sufficient to lower TC levels, nor is the effect of replacing dietary CO with CSO on other indices of cholesterol status (e.g., the levels of high-density lipoprotein cholesterol [HDL-C], non-HDL-C [i.e., very-low and low-density lipoprotein-cholesterol], or the TC/HDL-C ratio). Growing male rats were fed diets having CO, CSO, or a CO/CSO (1:1, w/w) oil mixture (OM) as the source of dietary oil (diet groups CO, CSO, and OM, respectively). There were no differences between CO and OM groups for TC, HDL-C, non-HDL-C, or the TC/HDL-C ratio. However, TC was significantly lower (p≤ 0.05)for the CSO group than the CO group (2.85 vs. 3.23 mmol/l, or 110 vs. 125 mg/dl, respectively) as was HDL-C (1.83 vs. 2.13 mmol/l, or 71 vs. 82 mg/dl, respectively), but there were no differences between these groups for non-HDL-C or the TC/HDL-C ratio. Diet had no effect on serum triglycerides (TGs) or on total liver content of either cholesterol or TGs. Thus, partial (50%) replacement of CO with CSO was without effect on any of these serum indices of cholesterol status, but total replacement resulted in lower TC and HDL-C, without affecting non-HDL-C or the TC/HDL-C ratio. Because, relative to CO, CSO has higher levels of saturated fatty acids but lower levels of monounsaturated and polyunsaturated fatty acids, the cholesterol-lowering effect of CSO appears to be unrelated to its fatty acid composition, and may be caused by a component of its nonsaponifiable fraction.

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References

  1. Jones LA, King CC (1996) Cottonseed oil. In: Hui YH (ed), Bailey's Industrial Oil and Fat Products, 5th edn. Vol. 2. Edible Oils and Fat Products: Oils and Oilseeds. New York: John Wiley, pp 159-240.

    Google Scholar 

  2. Balesdent D, Kapseu C, Kayem GJ (1989) Caractérisation des triglycérides de l'huile de coton par chromatographie liquide haute performance (CLHP) en une seule étape. Revue Fr Corps Grass 36: 27-33.

    Google Scholar 

  3. Hampden KA, Reber EF, Stewart G (1983) Effects of feeding whole kernel cottonseed on growth, reproduction and biochemical parameters. Fed Proc 42: 1323 (Abs.).

    Google Scholar 

  4. Edwards MS, Radcliffe JD (1995) A comparison of the effect of cottonseed oil and corn oil on lipid status in the rat. Biochem Arch 11: 103-109.

    Google Scholar 

  5. Criqui MH, Golomb BA (1998) Epidemiologic aspects of lipid abnormalities. Am JMed 105 (1A): 48S-57S.

    Google Scholar 

  6. Radcliffe JD, Morrison SD (1980) Protein quality, food intake and growth in normal and Walker 256 carcinosarcoma-bearing rats. J Nutr 110: 2182-2189.

    Google Scholar 

  7. Radcliffe J, Czajka Narins D, Imrhan V, Edwards M (1999) Effect of dietary fish oil on tumor-induced hyperlipidemia and tumor growth in rats implanted with a methylcholanthrene-induced sarcoma. Biochem Molecular Biol Int 47: 293-299.

    Google Scholar 

  8. AOAC (1984) Official Methods of Analysis, 14th edn. Washington, DC: Association of Official Analytical Chemists.

    Google Scholar 

  9. Radcliffe JD, Glass AC (1994) Dietary cottonseed protein can reduce the severity of retinoid-induced hypertriglyceridemia. Cancer Detect Prev 18: 401-406.

    Google Scholar 

  10. Lopes-Virella MF, Stone P, Ellis S, Colwell JA (1977) Cholesterol determination in highdensity lipoproteins separated by three different methods. Clin Chem 23: 882-884.

    Google Scholar 

  11. Folch J, Lees M, Sloane Stanley GH (1957) A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 226: 497-509.

    Google Scholar 

  12. Zar JH (1984) Biostatistical Analysis,2nd edn. Englewood Cliffs: Prentice Hall.

    Google Scholar 

  13. Armitage P, Berry G (1987) Statistical Methods in Medical Research, 2nd edn. Oxford: Blackwell.

    Google Scholar 

  14. Wardlaw GM, Snook JT (1990) Effect of diets high in butter, corn oil, or high-oleic acid sunflower oil on serum lipids and apoliporoteins in men. Am J Clin Nutr 51: 815-821.

    Google Scholar 

  15. Mensink RP (1993) Effects of the individual saturated fatty acids on serum lipids and lipoprotein concentrations. Am J Clin Nutr 57: 711S-714S.

    Google Scholar 

  16. Grundy SM, Denke MA (1990) Dietary influences on serum lipids and lipoproteins. J Lipid Res 31: 1149-1172.

    Google Scholar 

  17. Purushothama S, Raina PL, Hariharan K (1995) Effect of long term feeding of rice bran oil upon lipids and lipoproteins in rats. Mol Cell Biochem 146: 63-69.

    Google Scholar 

  18. Tajima K, Sakamoto M, Okada K, Mukai K, Ishizu K, Sakurai H, Mori H (1983) Reaction of biological phenolic antioxidants with superoxide generated by cytochrome P-450 model system. Biochem Biophys Res Commun 115: 1002-1008.

    Google Scholar 

  19. Rukmini C, Raghuram TC (1991) Nutritional and biochemical aspects of the hypolipidemic action of rice bran oil: a review. J Am Coll Nutr 10: 593-601.

    Google Scholar 

  20. Rong N, Ausman LM, Nicolosi RJ (1997) Oryzanol decreases cholesterol absorption and aortic fatty streaks in hamsters. Lipids 32: 303-309.

    Google Scholar 

  21. Seetharamaiah GS, Chandrasekhara N (1990) Effect of oryzanol on cholesterol absorption and biliary and fecal bile acids in rats. Indian J Med Res 92: 471-475.

    Google Scholar 

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Radcliffe, J., King, C., Czajka-Narins, D. et al. Serum and liver lipids in rats fed diets containing corn oil, cottonseed oil, or a mixture of corn and cottonseed oils. Plant Foods Hum Nutr 56, 51–60 (2001). https://doi.org/10.1023/A:1008189503099

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