Virus Genes

, Volume 20, Issue 3, pp 227–236

Capsid Protein Diversity among Norwalk-like Viruses

  • Jonathan Green
  • Jan Vinje
  • Chris I. Gallimore
  • Marion Koopmans
  • Antony Hale
  • David W.G. Brown
Article

DOI: 10.1023/A:1008140611929

Cite this article as:
Green, J., Vinje, J., Gallimore, C.I. et al. Virus Genes (2000) 20: 227. doi:10.1023/A:1008140611929

Abstract

We have determined the complete capsid gene sequence of 20 Norwalk-like viruses (NLVs) collected predominantly from outbreaks in the UK between 1989 and 1996. These comprised nine genogroup I and eleven genogroup II strains. Phylogenetic analysis of these and 15 published sequences suggest seven genomic sub-groups within genogroup I, including three previously described. In genogroup II, eight sub-groups were apparent, of which four were novel. Amino acid identities between strains of distinct genogroups ranged from 37 to 44% while varying between 61 and 100% for strains within a genogroup. Separate phylogenetic analyses of the N-terminus and central variable region of the capsid showed good correlation. Sequence divergence between strains was greatest within the central variable region, with amino acid sequence identities as low as 28% within a genogroup. These 15 genomic sub-groups provide a framework for further investigations of genetic and antigenic relationships within this calicivirus clade.

NLVs capsids SRSVs viral gastroenteritis calicivirus phylogenetic analysis 

Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • Jonathan Green
    • 1
  • Jan Vinje
    • 2
  • Chris I. Gallimore
    • 1
  • Marion Koopmans
    • 2
  • Antony Hale
    • 1
  • David W.G. Brown
    • 1
  1. 1.Enteric and Respiratory Virus LaboratoryCentral Public Health LaboratoriesLondon
  2. 2.National Institute for Public Health and Environmental Health and ProtectionRIVMBilthovenThe Netherlands

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