Plant Foods for Human Nutrition

, Volume 52, Issue 3, pp 231–239 | Cite as

Toxicity studies in mice of common spices, Cinnamomum zeylanicum bark and Piper longum fruits

  • A.H. Shah
  • A.H. Al-Shareef
  • A.M. Ageel
  • S. Qureshi


Acute (24 hours) and chronic (90 days) oral toxicity studies on the ethanolic extracts of common spices Cinnamomum zeylanicum Nees bark and Piper longum L. fruits were carried out in mice. Acute dosages were 0.5, 1.0 and 3 g/kg while the chronic dosage was 100 mg/kg/day. All external morphological, hematological and spermatogenic changes, in addition to body weight and vital organ weights, were recorded. The extracts of both the plants caused no significant acute or chronic mortality compared to the control during this study. During chronic treatment there was no significant change in the pre- and post treatment body weight of the test animals while the weight gain in the control group was significant. C. zeylanicum treatment caused reduction in liver weight while P. longum caused a significant increase in the weight of the lungs and spleen of the treated animals compared to the control. Hematological studies revealed a significant fall in hemoglobin level of C. zeylanicum treated animals. Both of the extracts induced a significant increase in reproductive organ weights, sperm motility, sperm count and failed to illicit any spermatotoxic effect.

Common spices Cinnamomum zeylanicum bark Piper longum fruits Acute toxicity Chronic toxicity Spermatogenic changes 


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Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • A.H. Shah
    • 1
  • A.H. Al-Shareef
    • 1
  • A.M. Ageel
    • 2
  • S. Qureshi
    • 2
  1. 1.Central Laboratory for Drug and Food Analysis, M.O.H.Riyadh-Saudi Arabia
  2. 2.Department of Pharmacology, College of PharmacyKing Saud UniversityRiyadhSaudi Arabia

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