A Novel Method to Obtain a β-Cyclodextrin Inclusion Compound by Solid State Reaction: the Ketoprofen Case Revisited
- 101 Downloads
The ketoprofen/beta-cyclodextrin (β-CD) inclusion compounds may be conveniently obtained through a solid state reaction at room temperature in the presence of saturated water vapour. Relative to the corresponding complexes produced with the usual coprecipitation method, the new compounds have a higher ketoprofen content and/or different properties. In particular, the formation reaction is not accompanied by a loss of hydration water, which is released in distinct stages upon heating. The thermodynamics of the dehydration process is discussed.
Unable to display preview. Download preview PDF.
- 1.D. Amdidouche, H. Darrouzet, D. Duchene and M. C. Poelman: Int. J. Pharm. 54, 175 (1989).Google Scholar
- 2.S. Y. Lin and Y. H. Kao, Int. J. Pharm. 69, 211 (1991).Google Scholar
- 3.Y. Nakai, K. Yamamoto, K. Terada, and D. Watanabe: Chem. Pharm. Bull. 35, 4609 (1987).Google Scholar
- 4.Y. Nakai, K. Yamamoto, K. Terada, T. Oguchi, H. Saito, and D. Watanabe, Chem. Pharm. Bull. 37, 1055 (1989).Google Scholar
- 5.Y. Nakai, K. Yamamoto, T. Oguchi, E. Yonemochi, and T. Hanawa: Chem. Pharm. Bull. 38, 1345 (1990).Google Scholar
- 6.Y. Nakai, K. Yamamoto, T. Oguchi, E. Yonemochi, and T. Hanawa, Chem. Pharm. Bull. 39, 1532 (1991).Google Scholar
- 7.A. Marini, V. Berbenni, G. Bruni, P.Mustarelli, F. Giordano, and M. Villa, J. Incl. Phenom. 22, 221 (1995).Google Scholar
- 8.A. Marini, V. Berbenni, G. Bruni, V. Massarotti, P. Mustarelli and M. Villa, J. Chem. Phys. 103, 7532 (1995).Google Scholar
- 9.B. Zhang and R. Breslow, J. Am. Chem. Soc. 115, 9353 (1993).Google Scholar
- 10.Y. Inoue, Y. Liu, L. Tong, B. Shen, and D. Jin, J. Am. Chem. Soc. 115, 10637 (1993).Google Scholar