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A Novel Method to Obtain a β-Cyclodextrin Inclusion Compound by Solid State Reaction: the Ketoprofen Case Revisited

  • G. Bruni
  • A. Marini
  • V. Berbenni
  • R. Riccardi
  • M. Villa
Article

Abstract

The ketoprofen/beta-cyclodextrin (β-CD) inclusion compounds may be conveniently obtained through a solid state reaction at room temperature in the presence of saturated water vapour. Relative to the corresponding complexes produced with the usual coprecipitation method, the new compounds have a higher ketoprofen content and/or different properties. In particular, the formation reaction is not accompanied by a loss of hydration water, which is released in distinct stages upon heating. The thermodynamics of the dehydration process is discussed.

β-Cyclodextrin ketoprofen hydration 

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References

  1. 1.
    D. Amdidouche, H. Darrouzet, D. Duchene and M. C. Poelman: Int. J. Pharm. 54, 175 (1989).Google Scholar
  2. 2.
    S. Y. Lin and Y. H. Kao, Int. J. Pharm. 69, 211 (1991).Google Scholar
  3. 3.
    Y. Nakai, K. Yamamoto, K. Terada, and D. Watanabe: Chem. Pharm. Bull. 35, 4609 (1987).Google Scholar
  4. 4.
    Y. Nakai, K. Yamamoto, K. Terada, T. Oguchi, H. Saito, and D. Watanabe, Chem. Pharm. Bull. 37, 1055 (1989).Google Scholar
  5. 5.
    Y. Nakai, K. Yamamoto, T. Oguchi, E. Yonemochi, and T. Hanawa: Chem. Pharm. Bull. 38, 1345 (1990).Google Scholar
  6. 6.
    Y. Nakai, K. Yamamoto, T. Oguchi, E. Yonemochi, and T. Hanawa, Chem. Pharm. Bull. 39, 1532 (1991).Google Scholar
  7. 7.
    A. Marini, V. Berbenni, G. Bruni, P.Mustarelli, F. Giordano, and M. Villa, J. Incl. Phenom. 22, 221 (1995).Google Scholar
  8. 8.
    A. Marini, V. Berbenni, G. Bruni, V. Massarotti, P. Mustarelli and M. Villa, J. Chem. Phys. 103, 7532 (1995).Google Scholar
  9. 9.
    B. Zhang and R. Breslow, J. Am. Chem. Soc. 115, 9353 (1993).Google Scholar
  10. 10.
    Y. Inoue, Y. Liu, L. Tong, B. Shen, and D. Jin, J. Am. Chem. Soc. 115, 10637 (1993).Google Scholar

Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • G. Bruni
    • 1
  • A. Marini
    • 1
  • V. Berbenni
    • 1
  • R. Riccardi
    • 1
  • M. Villa
    • 2
  1. 1.C.S.G.I. – Dipartimento di Chimica FisicaPaviaItaly
  2. 2.I.N.F.M., Unitá di PaviaPaviaItaly

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