Complexation of the Non-steroidal Anti-inflammatory Drug Nabumetone with Modified and Unmodified Cyclodextrins

  • Margarita Valero
  • Silvia M. B. Costa
  • José R. Ascenso
  • M. Mercedes Velázquez
  • Licesio J. Rodríguez
Article

Abstract

The inclusion of the anti-inflammatory drug, Nabumetone, in α-, β- and hydroxypropyl-β-cyclodextrin (CDs) is studied using UV-VIS absorption and steady-state fluorescence emission. Binding constants and thermodynamic parameters of complex formation are determined by spectrofluorimetry. The inclusion phenomena of Nabumetone with the three cyclodextrins is compared with that of the well known similar anti-inflammatory drug Naproxen. In the case of Nabumetone pronounced differences are observed in the complexation process with each cyclodextrin whereas the respective Naproxen complexes are nearly identical. 1H-NMR experiments show that the inclusion process in Nabumetone can occur either through the substituents in the -2 (butanone) or -6 (methoxy) positions in the naphthalene ring.

Nabumetone Naproxen cyclodextrin UV-absorption spectroscopy fluorescence spectroscopy thermodynamics proton NMR 

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Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • Margarita Valero
    • 1
    • 2
  • Silvia M. B. Costa
    • 1
  • José R. Ascenso
    • 1
  • M. Mercedes Velázquez
    • 2
  • Licesio J. Rodríguez
    • 2
  1. 1.Centro de Química Estrutural, Complexo InterdisciplinarInstituto Superior TécnicoLisboaPortugal
  2. 2.Departamento de Química-Física, Facultad de FarmaciaUniversidad de SalamancaSalamancaSpain

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