Cytotechnology

, 24:89

Some myths and messages concerning the batch and continuous culture of animal cells

  • A. Kadouri
  • R.E. Spier
Article

DOI: 10.1023/A:1007932614011

Cite this article as:
Kadouri, A. & Spier, R. Cytotechnology (1997) 24: 89. doi:10.1023/A:1007932614011

Abstract

lt is often assumed that continuous processes are more difficult and less productive than a suite of batch processes for the production of a particular biomolecule. This paper cites two papers which have appeared in the literature which propound this view and examines in detaü the justification for the support of this contention. After reviewing those features where it is alleged that continuous processes are at a disadvantage, the authors of this paper conclude that the opposite is the case and that for suitable processes the most effective way of generating product is by the use of fully continuous processes. The choice of a particular process dependends on a variety of fixed and variable factors which are unique to the process. These factors are discussed and two decision trees are presented which are designed to facilitate the choice of the appropriate process technology.

batch continuous processes myths messages process selection 

Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • A. Kadouri
    • 1
  • R.E. Spier
    • 1
  1. 1.Weizmann Institute for Science, Rehovot, Israel and School of Biological SciencesUniversity of SurreyUK

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