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Fish Physiology and Biochemistry

, Volume 19, Issue 1, pp 13–21 | Cite as

Effects of insulin-like growth factor-I on final oocyte maturation and steroid production in Fundulus heteroclitus

  • Z. Negatu
  • S.M. Hsiao
  • R.A. Wallace
Article

Abstract

Recent evidence has indicated the presence of IGF-I and IGF-I receptors in mammalian and teleost ovarian follicles. Since growth hormone (GH), which can be secreted from the pituitary concomitant with a gonadotropin as a response to gonadotropin-releasing hormone, generally acts to release IGF-I from tissues including the ovary, the effect of IGF-I itself on ovarian steroidogenesis and oocyte maturation was investigated in the model teleost, Fundulus heteroclitus. IGF-I was found to be without effect on ovarian follicle steroidogenesis, but initiated oocyte maturation in a dose-dependent manner even more rapidly and effectively than 17α,20β-dihydroxy-4-pregnene-3-one (DHP), the naturally occurring maturation-inducing steroid. IGF-II also induced oocyte maturation in a dose-dependent manner. IGF-I induction of oocyte maturation occurred in the absence of DHP production by the granulosa cells (which is normally stimulated by gonadotropin), and could be inhibited by cycloheximide but not actinomycin D, thus implicating the role of protein synthesis. These results suggest that GH-stimulated release of ovarian IGF-I may have an even more direct role than DHP on the reinitiation of oocyte maturation.

estradiol Fundulus heteroclitus growth hormone IGF-I IGF-II oocyte maturation ovarian follicle steroidogenesis signal transduction testosterone 

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Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  1. 1.Whitney Laboratory of University of FloridaUSA
  2. 2.Department of Anatomy and Cell Biology, College of MedicineUniversity of FloridaGainesvilleUSA

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