Acute Multiple Sclerosis Characterized by Extensive Mononuclear Phagocyte Infiltration
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- Shields, D.C., Avgeropoulos, N.G., Banik, N.L. et al. Neurochem Res (2000) 25: 1517. doi:10.1023/A:1007636427861
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In this study, we examine the clinical, neuroradiological, and immunohistochemical findings of a 51 year old white female who died 27 months after onset of acute multiple sclerosis despite treatment with interferon-β, azathioprine, corticosteroids, and cyclophosphamide. Immunohistochemical studies revealed extensive gliosis and mononuclear phagocyte infiltration with corresponding upregulation of proinflammatory cytokines (eg. IFN-α, TNF-α). The significance of immunohistochemical findings with respect to clinical presentation is discussed.