Neurochemical Research

, Volume 25, Issue 11, pp 1517–1520

Acute Multiple Sclerosis Characterized by Extensive Mononuclear Phagocyte Infiltration

  • Donald C. Shields
  • Nicholas G. Avgeropoulos
  • Naren L. Banik
  • William R. Tyor


In this study, we examine the clinical, neuroradiological, and immunohistochemical findings of a 51 year old white female who died 27 months after onset of acute multiple sclerosis despite treatment with interferon-β, azathioprine, corticosteroids, and cyclophosphamide. Immunohistochemical studies revealed extensive gliosis and mononuclear phagocyte infiltration with corresponding upregulation of proinflammatory cytokines (eg. IFN-α, TNF-α). The significance of immunohistochemical findings with respect to clinical presentation is discussed.

Multiple sclerosis mononuclear phagocyte interferon alpha tumor necrosis factor alpha 


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Copyright information

© Plenum Publishing Corporation 2000

Authors and Affiliations

  • Donald C. Shields
    • 1
  • Nicholas G. Avgeropoulos
    • 2
  • Naren L. Banik
    • 1
  • William R. Tyor
    • 3
  1. 1.Department of NeurologyMedical University of South CarolinaCharleston
  2. 2.Brain Tumor Center, Department of NeurologyMassachusetts General HospitalBoston
  3. 3.Department of NeurologyMedical University of South CarolinaCharleston

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