European Journal of Epidemiology

, Volume 14, Issue 5, pp 491–494 | Cite as

Prevalence of Helicobacter pylori infection in two Spanish regions with different incidence of gastric cancer

  • A. Senra-Varela
  • J.B. Lopez-Saez
  • V. Gomez-Biondi


It is a cross-sectional study, comparing the prevalence of Helicobacter pylori infection (prevalence of IgG antibodies to H. pylori) in the healthy population of Ubrique and Grazalema (mountain location, mortality from stomach cancer 20/100,000) and in Barbate, (coastal location, mortality from stomach cancer 10/100,000) in the province of Cádiz, southern Spain. The subjects were randomly selected, 163 men and 169 women, 18 years or older; 179 persons were studied in the inland, and 154 in the littoral in January 1997. Of the 332 subjects investigated, 43% were positive, a mean antibody titer of 337 IU/l (95% CI: 254–420), and 56% were negative, with a mean titer of 18 IU/l (95% CI: 15–19). In the coastal population, 30% has positive titers and 54% in the mountain location. By age: 18–40 years, 30% of littoral and 41% of inland population had positive titers; 41–60 years, 35% of those living in the littoral and 58% of inland population had positive titers; > 60 years, 24% of coastal inhabitants and 62% of those living in the inland had positive titers. Living in mountain locations in the province of Cádiz involves a greater ecological risk for H. pylori infection (p < 0.05).

Altitude Gastric cancer Geographic location Healthy subjects Helicobacter pylori infection 


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  1. 1.
    Palmeiro R, Senra A, García-Blanco P, Millán J. Changing patterns of gastric cancer mortality in Spain. Cancer Letters 1988; 42: 99–102.CrossRefPubMedGoogle Scholar
  2. 2.
    Instituto Nacional de Estadística. Anuario Estadístico. Madrid: INE, 1994.Google Scholar
  3. 3.
    Gómez Biondi V. Infección por Helicobacter pylori en dos poblaciones con distinto riesgo de cáncer gástrico [Tesis Doctoral]. Cádiz: Universidad de Cádiz, 1996.Google Scholar
  4. 4.
    Waitt JI. Gastritis and its relation to gastric carcinogenesis. Sem Diag Path 1991; 8: 137–148.Google Scholar
  5. 5.
    Blaser MJ, Chyou PH, Nomura A. Age at establishment of Helicobacter pylori infection and gastric carcinoma, gastric ulcer, and duodenal ulcer risk. Cancer Res 1995; 55: 562–565.PubMedGoogle Scholar
  6. 6.
    Blaser MJ. Helicobacter pylori: Its role in disease. Clin Infect Dis 1992; 15: 386–391.PubMedGoogle Scholar
  7. 7.
    Dooley CP, Cohen H. The clinical significance of Campylobacter pylori. Ann Int Med 1988; 108: 70–79.PubMedGoogle Scholar
  8. 8.
    Correa P. Human gastric carcinogenesis: A multistep and multifactorial process. Cancer Res 1992; 52: 6735–6740.PubMedGoogle Scholar
  9. 9.
    Dunn BE. Pathogenic mechanisms of Helicobacter pylori. Gastroenterol Clin North Am 1993; 22:43–57.PubMedGoogle Scholar
  10. 10.
    Tytgat GNJ. Does the stomach adapt to Helicobacter pylori? Scand J Gastroenterol 1992; 27:(Suppl. 193): 28–32.Google Scholar
  11. 11.
    Bontkes HJ, Veenendal RA, Peña AS, et al. IgG subclass response to Helicobacter pylori in patients with chronic active gastritis and duodenal ulcer. Scand J Gastroenterol 1992; 27: 129–133.PubMedGoogle Scholar
  12. 12.
    Instituto Nacional de Estadística. Movimientos Naturales de la Población. Defunciones Según la Causa de Muerte. 1992. Tomo I. Resultados Básicos. Madrid: INE, 1995.Google Scholar
  13. 13.
    Andersen LP, Raskow H, Elsborg L, et al. Prevalence of antibodies against heat-stable antigens from Helicobacter pylori in patients with dyspeptic symptoms and normal persons. APMIS 1992; 100: 779–789.PubMedGoogle Scholar
  14. 14.
    Wilkison L. Systat: The System for Statistics. Evanston: Systat, Inc, 1990.Google Scholar
  15. 15.
    Gardner MJ, Altman DG. Statistics with confidence. London: BMJ, 1992.Google Scholar
  16. 16.
    Strike PW. Statistical methods in laboratory medicine. Oxford: Butterworth-Heinemann, 1991: 331–381.Google Scholar
  17. 17.
    Cayetano HP. Ecology of Helicobacter pylori in Peru: Infection rates in coastal, high altitude, and jungle communities. Gut 1992; 33: 604–605.PubMedGoogle Scholar
  18. 18.
    Malaty HM, Graham DY. Importance of childhood sociocconomic status on the current prevalence of Helicobacter pylori infection. Gut 1994; 35: 742–745.PubMedGoogle Scholar
  19. 19.
    Boeing H. Epidemiological research in stomach cancer: Progress over the last ten years. J Cancer Res Clin Oncol 1991; 117: 133–143.PubMedGoogle Scholar
  20. 20.
    Graham DY, Adam E, Reddy GT, et al. Seroepidemiology of Helicobacter pylori infection in India. Compari son of developing and developed countries. Dig Dis Sci 1991; 36: 1084–1088.PubMedGoogle Scholar
  21. 21.
    Lin JT, Wang LY, Wang JT, Wang TH, Chen CJ. Ecological study of association between Helicobacter pylori infection and gastric cancer in Taiwan. Dig Dis Sci 1995; 40: 385–388.PubMedGoogle Scholar
  22. 22.
    Mendall MA, Goggin PM, Molineaux N, Levy J, Toosy T, Strachan D, Northfield TC. Childhood living conditions and Helicobacter pylori seropositivity in adult life. Lancet 1992; 339: 896–897.CrossRefPubMedGoogle Scholar
  23. 23.
    Asaka M, Kimura T, Kudo M, et al. Relationship of Helicobacter to serum pepsinogens in an asymptomatic Japanese population. Gastroenterology 1992; 102: 760–766.PubMedGoogle Scholar
  24. 24.
    Clearfield HR. Helicobacter pylori: Aggressor or innocent bystander? Med Clin North Am 1991; 75: 815–829.PubMedGoogle Scholar
  25. 25.
    Vaira D, Ferron P, Negrini R, et al. Detection of Helicobacter pylori-like organisms in the stomach of some food-source animals using a monoclonal antibody. Ital J Grastoenterol 1992; 24: 181–184.Google Scholar
  26. 26.
    Vaira D, Holton J, Ainley CC, et al. The source of Campylobacter pylori. Biomed Pharmacother 1989; 43: 447–450.CrossRefPubMedGoogle Scholar

Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • A. Senra-Varela
    • 1
  • J.B. Lopez-Saez
    • 1
  • V. Gomez-Biondi
    • 1
  1. 1.Grupo de Investigación Oncológica, Departamento de Medicina, Facultad de MedicinaUniversidad de CádizCádizSpain

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