European Journal of Epidemiology

, Volume 13, Issue 8, pp 931–935 | Cite as

Serum immunoglobulins E are related to menstrual cycle

  • Mariella Vellutini
  • Giovanni Viegi
  • Donatella Parrini
  • Marzia Pedreschi
  • Sandra Baldacci
  • Paola Modena
  • Batrizia Biavati
  • Marzia Simoni
  • Laura Carrozzi
  • Carlo Giuntini


During a cross sectional epidemiological survey on a general population sample, 596 fertile women underwent total serum IgE detemination. They completed an interviewer-administered standardized questionnaire and were categorized according to their menstrual period. They were divided into two groups: those from days 10 to 20, who were considered to be in the periovulatory phase, and those in the other phases. IgE mean values were significantly different (p = 0.01) in the two groups: particularly, lower IgE values were found in those in periovulatory phase, after accounting for smoking habit and atopic status. By multiple regression analysis, taking into account the independent effects of menstrual period, age, smoking habit, hours of fast, skin prick test reactivity and presence of cough, significantly lower IgE values in the periovulatory phase were found. We hypothesize the possibility that a decrease of IgE concentration occurs during midcycle: a reduced immune response might facilitate the ovuli implantation. Further studies are necessary to longitudinally investigate the trend of IgE in the same women, as well as the distributions and the trends of other immunoglobulins.

Epidemiological survey General population IgE Menses Questionnaire 


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Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • Mariella Vellutini
    • 1
  • Giovanni Viegi
    • 1
  • Donatella Parrini
    • 2
  • Marzia Pedreschi
    • 1
  • Sandra Baldacci
    • 1
  • Paola Modena
    • 1
  • Batrizia Biavati
    • 3
  • Marzia Simoni
    • 3
  • Laura Carrozzi
    • 1
  • Carlo Giuntini
    • 1
  1. 1.CNR Institute of Clinical Physiology and Second Division of Internal MedicineUniversity of PisaItaly
  2. 2.Institute of ObstetricsUniversity of PisaItaly
  3. 3.Institute of General PathologyUniversity of FerraraItaly

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