Glycoconjugate Journal

, Volume 17, Issue 5, pp 331–338

Expression of H type 1 antigen of ABO histo-blood group in normal colon and aberrant expressions of H type 2 and H type 3/4 antigens in colon cancer

  • Noboru Fujitani
  • Yuhua Liu
  • Shuji Toda
  • Kazuo Shirouzu
  • Torahiko Okamura
  • Hiroshi Kimura
Article

DOI: 10.1023/A:1007173722426

Cite this article as:
Fujitani, N., Liu, Y., Toda, S. et al. Glycoconj J (2000) 17: 331. doi:10.1023/A:1007173722426

Abstract

We have immunohistochemically examined the distribution of the H antigens of type 1, type 2 and type 3/4 chains of the ABO(H) histo-blood group system in human normal colon and in colon cancer using three monoclonal antibodies specific for each of the H type 1/2, H type 2, and the H type 3/4 chain. We unexpectedly found that mucosa of the normal colon from secretors but not that from nonsecretors expressed only H type 1 and did not express H type 2 or H type 3/4. The H type 1 was expressed in goblet cells. Positive goblet cells expressing H type 1 were decreased in number progressively from the proximal colon to the rectum. In tumors, 4 (57%) of 7 cancer tissues of the proximal colon from secretors expressed no H type 1, whereas all 8 cancer tissues of the distal colon from secretors expressed H type 1. The aberrant expressions of H type 2 and H type 3/4 (47 and 67%, respectively) were found in cancer tissues from both the proximal and the distal colon. Tumors from nonsecretors did not express any H antigens. Our results suggested that the expression of H type 1 in the normal colon and the aberrant expressions of H type 2 and H type 3/4 in colon cancer tissues were regulated by FUT2-encoded Se type α(1,2)fucosyltransferase. However, UEA-I-positive substance(s) rather than H type 2 were uniquely expressed throughout the normal colon and in colon cancers from both secretors and nonsecretors.

colon colon cancer H antigen secretor ABO anti-H antibody 

Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • Noboru Fujitani
    • 1
    • 2
  • Yuhua Liu
    • 1
  • Shuji Toda
    • 3
  • Kazuo Shirouzu
    • 4
  • Torahiko Okamura
    • 1
  • Hiroshi Kimura
    • 1
  1. 1.Department of Forensic Medicine and Human GeneticsKurume University School of MedicineKurume
  2. 2.Department of Biochemistry, Faculty of ScienceOkayama University of ScienceOkayama
  3. 3.Department of PathologySaga Medical SchoolSaga
  4. 4.Department of SurgeryKurume University School of MedicineKurumeJapan

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