International Urology and Nephrology

, Volume 32, Issue 1, pp 19–27 | Cite as

Kinetic versus thermodynamic factors in calcium renal lithiasis

  • Felix Grases
  • Antonia Costa-Bauzá
  • Erich Königsberger
  • Lan-Chi Königsberger


Calcium renal lithiasis formation depends on the balance between thermodynamic (supersaturation) and kinetic (inhibitors, nucleants)factors. In this paper, the importance of both groups was evaluated using(a) the complete urine analysis data obtained from 32 healthy volunteers and 141 active stone-formers, and (b) a comprehensive computer model to calculate the supersaturation values of calcium oxalate monohydrate,hydroxyapatite and brushite in each urine sample. The results of this evaluation were used to assess the possible effectiveness of a given pharmacological treatment.

Calcium calculi Lithogen risk Renal lithiasis 


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Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • Felix Grases
    • 1
  • Antonia Costa-Bauzá
    • 1
  • Erich Königsberger
    • 2
  • Lan-Chi Königsberger
    • 2
  1. 1.Laboratory of Renal Lithiasis ResearchUniversity of Illes BalearsPalma de MallorcaSpain
  2. 2.Department of Physical ChemistryUniversity of LeobenLeobenAustria

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