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Molecular and Cellular Biochemistry

, Volume 203, Issue 1–2, pp 185–187 | Cite as

Vanadium and diabetes. What about vanadium toxicity?

  • Jose L. Domingo
Article

Keywords

Vanadium Vanadium Toxicity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Poucheret P, Verma S, Grynpas MD, McNeill JH: Vanadium and diabetes. Mol Cell Biochem 188: 73-80, 1998Google Scholar
  2. 2.
    Cohen N, Halberstam M, Shlimovich P, Chang CJ, Shamoon H, Rosetti L: Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 95: 2501-2509, 1995Google Scholar
  3. 3.
    Goldfine AB, Simonson DC, Folli F, Patti ME, Kahn CR: Metabolic effects of sodium metavanadate in humans with insulin-dependent and noninsulin-dependent diabetes mellitus in vivo and in vitro studies. J Clin Endocrinol Metab 80: 3311-3320, 1995Google Scholar
  4. 4.
    Boden G, Chen X, Ruiz J, van Rossum GDV, Turco S: Effects of vanadyl sulfate on carbohydrate and lipid metabolism in patients with non-insulin-dependent diabetes mellitus. Metabolism 45: 1130-1135, 1996Google Scholar
  5. 5.
    Halberstam M, Cohen N, Shlimovich P, Rosetti L, Shamoon H: Oral vanadyl sulfate improves insulin sensitivity in NIDDM but not in obese nondiabetic subjects. Diabetes 45: 659-666, 1996Google Scholar
  6. 6.
    Somerville J, Davies B: Effect of vanadium on serum cholesterol. Am Heart J 64: 54-56, 1992Google Scholar
  7. 7.
    Fawcett JP, Farquhar SJ, Thou T, Shand BI: Oral vanadyl sulfate does not affect blood cells, viscosity or biochemistry in humans. Pharmacol Toxicol 80: 202-206, 1997Google Scholar
  8. 8.
    Tsiani E, Fantus IG: Vanadium compounds. Biological actions and potential as pharmacological agents. Trends Endocrinol Metab 8: 51-58, 1997Google Scholar
  9. 9.
    Hamel FG, Duckworth WC: The relationship between insulin and vanadium metabolism in insulin target tissues. Mol Cell Biochem 153: 95-102, 1995Google Scholar
  10. 10.
    Domingo JL, Gomez M, Sanchez DJ, Llobet JM, Keen CL: Toxicology of vanadium compounds in diabetic rats: The action of chelating agents on vanadium accumulation. Mol Cell Biochem 153: 233-240, 1995Google Scholar
  11. 11.
    Srivastava AK: Potential use of vanadium compounds in the treatment of diabetes mellitus. Exp Opin Invest Drugs 4: 525-536, 1995Google Scholar
  12. 12.
    Martin BD, Felty A, Stearns, DM, Wetterhahn KE: Vanadium: Quantitation, essentiality, and pharmacologic and toxicological studies in rodents. In: R.R. Watson, I. Wolinsky (eds). Methods in Nutrition Research. CRC Press, Boca Raton, FL, 1997, pp 325-354Google Scholar
  13. 13.
    Bischoff H, Lebovitz HE: Oral antidiabetic drugs in research and development. In: J. Kuhlmann, W. Puls (eds). Handbook of Experimental Pharmacology, vol. 119. Springer-Verlag, Berlin, 1996, pp 651-696Google Scholar
  14. 14.
    Sabbioni E, Pozzi G, Devos S, Pintar A, Casella L, Fischbach M: The intensity of vanadium (V)-induced cytoxicity and morphological transformation in BALB/3T3 cells is dependent on glutathionemediated bioreduction to vanadium (IV). Carcinogenesis 14: 2565-2568, 1993Google Scholar
  15. 15.
    Ciranni R, Antonetti M, Migliore L: Vanadium salts induce cytogenetic effects in in vivo treated mice. Mutat Res 343: 53-60, 1995Google Scholar
  16. 16.
    Domingo JL: Vanadium: A review of the reproductive and developmental toxicity. Reprod Toxicol 10: 175-182, 1996Google Scholar
  17. 17.
    Ganguli S, Reuland DJ, Franklin LA, Tucker M: Effect of vanadate on reproductive efficiency in normal and streptozotocin-treated diabetic rats. Metabolism 43: 1384-1388, 1994Google Scholar
  18. 18.
    Ganguli S, Reuland DJ, Franklin LA, Deakins DD, Johnston WJ, Pasha A: Effects of maternal vanadate treatment on fetal development. Life Sci 55: 1267-1276, 1994Google Scholar
  19. 19.
    Shi X, Jiang H, Mao Y, Ye J, Saffiotti U: Vanadium (IV)-mediated free radical generation and related 2¢-deoxyguanosine hydroxylation and DNA damage. Toxicology 106: 27-38, 1996Google Scholar
  20. 20.
    Cortizo AM, Salice V, Vescina CM, Etcheverry SB: Proliferative and morphological changes induced by vanadium compounds on Swiss 3T3 fibroblasts. Biometals 10: 127-133, 1997Google Scholar
  21. 21.
    Sanchez DJ, Colomina MT, Domingo JL: Effects of vanadium on activity and learning in rats. Physiol Behav 63: 345-350, 1998Google Scholar
  22. 22.
    De la Torre A, Granero S, Mayayo E, Corbella J, Domingo JL: Effect of age on vanadium nephrotoxicity in rats. Toxicol Lett 105: 75-82, 1999Google Scholar
  23. 23.
    Brichard SM, Okitolonda W, Henquin JC: Long term improvement of glucose homeostasis by vanadate treatment in diabetic rats. Endocrinology 123: 1022-1028, 1988Google Scholar
  24. 24.
    Brichard SM, Bailey CJ, Henquin JC: Long term improvement of glucose homeostasis by vanadate in obese hyperinsulinemic rats. Endocrinology 125: 2510-2516, 1989Google Scholar
  25. 25.
    Mongold JJ, Cros GH, Vian L, Tep A, Ramanadham S, Siou G, Diaz J, McNeill JH, Serrano JJ: Toxicological aspects of vanadyl sulfate on diabetic rats: Effects on vanadium levels and pancreatic B-cell morphology. Pharmacol Toxicol 67: 192-198, 1990Google Scholar
  26. 26.
    Dai S, Thompson KH, McNeill JH: One-year treatment of streptozotocin-induced diabetic rats with vanadyl sulfate. Pharmacol Toxicol 74: 101-109, 1994Google Scholar
  27. 27.
    Dai S, McNeill JH: One-year treatment of non-diabetic and streptozotocin-diabetic rats with vanadyl sulfate did not alter blood pressure or hematological indices. Pharmacol Toxicol 74: 110-115, 1994Google Scholar
  28. 28.
    Dai S, Thompson KH, Vera E, McNeill JH: Toxicity studies on oneyear treatment of non-diabetic and streptozotocin-induced diabetic rats with vanadyl sulfate. Pharmacol Toxicol 74: 265-273, 1994Google Scholar
  29. 29.
    Dai S, Vera E, McNeill JH: Lack of hematological effect of oral vanadium treatment in rats. Pharmacol Toxicol 76: 263-268, 1995Google Scholar
  30. 30.
    Reul BA, Amin SS, Buchet JP, Ongemba LN, Crans DC, Brichard SM: Effects of vanadium complexes with organic ligands on glucose metabolism: A comparison study in diabetic rats. Br J Pharmacol 126: 467-477, 1999Google Scholar

Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • Jose L. Domingo
    • 1
  1. 1.Laboratory of Toxicology and Environmental Health, School of Medicine'Rovira i Virgili' UniversityReusSpain

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