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Gaba and hepatocellular carcinoma

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Abstract

Data derived from models of hepatic regeneration indicate that transient, recipricol changes in polyamines, potent growth promoters, and gamma aminobutyric acid (GABA), an amino acid neurotransmitter with growth inhibitory properties, play important roles in enhancing and inhibiting respectively regulated hepatocyte proliferation. Based on these findings and supportive data derived from studies of human carcinoma tissues and malignant cell lines we propose that permanent increases in polyamine and decreases in GABAergic activity act in concert to contribute to the pathogenesis of hepatocellular carcinoma.

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Authors and Affiliations

  1. Liver Diseases Unit, Departments of Medicine and Pharmacology, University of Manitoba, Winnipeg, Manitoba, Canada

    G.Y. Minuk

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Minuk, G. Gaba and hepatocellular carcinoma. Mol Cell Biochem 207, 105–108 (2000). https://doi.org/10.1023/A:1007062802164

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  • DOI: https://doi.org/10.1023/A:1007062802164

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