Transition Metal Chemistry

, Volume 25, Issue 4, pp 456–460

Complexes of a tridentate ONS Schiff base. Synthesis and biological properties

  • M. Tofazzal H. Tarafder
  • Manaf A. Ali
  • D. Juan Wee
  • Kasbollah Azahari
  • Sidik Silong
  • Karen A. Crouse
Article
  • 768 Downloads

Abstract

Several new complexes of a tridentate ONS Schiff base derived from the condensation of S-benzyldithiocarbazate with salicylaldehyde have been characterised by elemental analyses, molar conductivity measurements and by i.r. and electronic spectra. The Schiff base (HONSH) behaves as a dinegatively charged ligand coordinating through the thiolo sulphur, the azomethine nitrogen and the hydroxyl oxygen. It forms mono-ligand complexes: [M(ONS)X], [M=NiII, CuII, CrIII, SbIII, ZnII, ZrIV or UVI with X = H2O, Cl]. The ligand produced a bis-chelated complex of composition [Th(ONS)2] with ThIV. Square-planar structures are proposed for the NiII and CuII complexes. Antimicrobial tests indicate that the Schiff base and five of the metal complexes of CuII, NiII, UVI, ZnII and SbIII are strongly active against bacteria. NiII and SbIII complexes were the most effective against Pseudomonas aeruginosa (gram negative), while the CuII complex proved to be best against Bacillus cereus (gram positive bacteria). Antifungal activities were also noted with the Schiff base and the UVI complex. These compounds showed positive results against Candida albicans fungi, however, none of them were effective against Aspergillus ochraceous fungi. The Schiff base and its zinc and antimony complexes are strongly active against leukemic cells (CD50 = 2.3–4.3 μg cm−3) while the copper, uranium and thorium complexes are moderately active (CD50 = 6.9–9.5 μg cm−3). The nickel, zirconium and chromium complexes were found to be inactive.

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References

  1. 1.
    M.A. Ali and S.E. Livingstone, Coord. Chem. Rev., 13, 101 (1974).CrossRefGoogle Scholar
  2. 2.
    M.A. Ali, S.E. Livingstone and D.J. Phillips, J. Chem. Soc. Chem. Commun., 179 (1972).Google Scholar
  3. 3.
    M.A. Ali and R. Bose, J. Inorg. Nucl. Chem., 39, 265 (1977).CrossRefGoogle Scholar
  4. 4.
    M.A. Ali and M.T.H. Tarafder, J. Inorg. Nucl. Chem., 39, 1785 (1977).CrossRefGoogle Scholar
  5. 5.
    M.T.H. Tarafder and M.A. Ali, Can. J. Chem., 58, 727 (1980).CrossRefGoogle Scholar
  6. 6.
    M.T.H. Tarafder, M.A. Ali, N. Saravanan, W.Y. Weng, S. Kumar, N. Umar-Tsafe and K.A. Crouse, Transition Met. Chem., (in press).Google Scholar
  7. 7.
    A.M. Ali, M.M. Mackeen, I.I. Safinar, M. Hamid, N.H. Lajis, S.H. El-sharkawy and M. Murakoshi, J. Ethnopharmacology, 53, 165 (1996).CrossRefGoogle Scholar
  8. 8.
    T. Mosmann, J. Immunol. Meth., 65, 55 (1983).CrossRefGoogle Scholar
  9. 9.
    W.J. Geary, Coord. Chem. Rev., 7, 81 (1971).CrossRefGoogle Scholar
  10. 10.
    M.A. Ali and R. Bose, Polyhedron, 3, 517 (1984).CrossRefGoogle Scholar
  11. 12.
    M.A. Ali, M.M. Kabir, M.N. Uddin, S.M.M.H. Majumder, M.T.H. Tarafder and M.A. Khair, Indian J. Chem., 27A, 1064 (1988).Google Scholar
  12. 13.
    M.A. Ali, D.A. Chowdhury-I and M. Nazim Uddin, Polyhedron, 3, 595 (1984).CrossRefGoogle Scholar
  13. 14.
    M.A. Ali, C.M. Haroon, M. Nazamuddin, S.M.M.H. Majumder, M.T.H. Tarafder and M.A. Khair, Transition Met. Chem., 17, 133 (1992).CrossRefGoogle Scholar
  14. 15.
    M.A. Ali, M. Uddin, M.N. Uddin, D.A. Chowdhury-I and M.T.H. Tarafder, Indian J. Chem., 25A, 238 (1986).Google Scholar
  15. 16.
    M.A. Ali, S.M.G. Hossain, S.M.M.H. Majumder, M.N. Uddin and M.T.H. Tarafder, Polyhedron, 6, 1653 (1987).CrossRefGoogle Scholar
  16. 17.
    B.N. Finggis, Introduction to Ligand Fields, Interscience, New York, 1967, p316.Google Scholar
  17. 18.
    H.B. Gray and C.J. Ballhausen, J. Am. Chem. Soc., 85, 260 (1963).CrossRefGoogle Scholar
  18. 19.
    R.W. Hay and M.T.H. Tarafder, J. Chem. Soc. Dalton Trans., 20, 823 (1991).CrossRefGoogle Scholar

Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • M. Tofazzal H. Tarafder
    • 1
  • Manaf A. Ali
    • 2
  • D. Juan Wee
    • 1
  • Kasbollah Azahari
    • 1
  • Sidik Silong
    • 1
  • Karen A. Crouse
    • 1
  1. 1.Department of ChemistryUniversiti Putra MalaysiaUPM Serdang, SelangorMalaysia
  2. 2.Department of BiotechnologyUniversiti Putra MalaysiaUPM Serdang, SelangorMalaysia

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