, Volume 146, Issue 1, pp 1–8 | Cite as

Cryptococcal meningitis in the immunocompromised host: intracranial hypertension and other complications

  • David A. Stevens
  • David W. Denning
  • Stanley Shatsky
  • Robert W. Armstrong
  • Jacqueline D. Adler
  • Bradley H. Lewis


Cryptococcosis as a complication of the immunocompromised host has dramatically increased in frequency since the start of the AIDS epidemic. This trend has heightened awareness of the complications of cryptococcal meningitis; of these, intracranial hypertension is common, severe, and life-threatening, as exemplified by three cases in our institutions presented here in detail. An aggressive approach to management of this complication has not been the standard of care, but neurosurgical interventional studies combined with physiologic observations suggest early intervention may reduce the devastating morbidity and mortality.

AIDS cryptococcosis fungal meningitis immunocompromised intracranial hypertension 


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Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • David A. Stevens
    • 1
    • 2
    • 3
  • David W. Denning
    • 4
  • Stanley Shatsky
    • 5
  • Robert W. Armstrong
    • 1
    • 2
    • 6
  • Jacqueline D. Adler
    • 1
    • 2
    • 3
  • Bradley H. Lewis
    • 7
  1. 1.Department of Medicine, Division of Infectious DiseasesSanta Clara Valley Medical CenterSan JoseUSA
  2. 2.Department of Medicine, Division of Infectious Diseases and Geographic MedicineStanford University School of MedicineStanfordUSA
  3. 3.California Institute for Medical ResearchSan JoseUSA
  4. 4.Department of Infectious Diseases and Tropical Medicine, North Manchester General Hospital and Section of Infectious DiseasesUniversity of Manchester, Hope HospitalManchester, EnglandUK
  5. 5.Department of Neurosurgery, Santa Clara Valley Medical Center andStanford University School of MedicineUSA
  6. 6.Department of MedicineGood Samaritan HospitalLos GatosUSA
  7. 7.Comprehensive Cancer Center and the Adult Hemophilia ProgramAlta Bates HospitalBerkeleyUSA

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