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Molecular and Cellular Biochemistry

, Volume 190, Issue 1–2, pp 119–124 | Cite as

Roles of intracellular Ca2+ receptors in the pancreatic β-cell in insulin secretion

  • Ichiro Niki
  • Hiroyoshi Hidaka
Article

Abstract

Ca2+ is the central second messenger in the regulation of insulin release from the pancreatic β-cell; and intracellular Ca2+-binding proteins, classified into two groups, the EF hand proteins and the Ca2+/ phospholipid binding proteins, are considered to mediate Ca2+ signaling. A number of Ca binding proteins have been suggested to participate in the secretory machinery in the β-cell. Calmodulin, the ubiquitous EF hand protein, is the predominant intracellular Ca2+ receptor that modulates insulin release via the multiplicity of its binding to target proteins including protein kinases. Other Ca binding proteins such as calcyclin and the Ca2+/phospholipid binding proteins may also be suggested to be involved. Ca2+ influx from the extracellular space appears to be responsible for exocytosis of insulin via Ca2+-dependent protein/protein interactions. On the other hand, intracellular Ca2+ mobilization resulting in secretory granule movement may be controlled by Ca2+/calmodulin-dependent protein phosphorylation. Thus, Ca2+ exerts versatile effects on the secretory cascade via binding to specific binding proteins in the pancreactic β-cells.

Ca2+ binding proteins secretory granules protein kinases 

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Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • Ichiro Niki
    • 1
  • Hiroyoshi Hidaka
    • 1
  1. 1.Department of PharmacologyNagoya University School of MedicineNagoyaJapan

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