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Mycopathologia

, Volume 141, Issue 2, pp 73–77 | Cite as

In vitro activity of a new triazole antifungal agent, Sch 56592, against clinical isolates of filamentous fungi

  • F. Marco
  • M.A. Pfaller
  • S.A. Messer
  • R.N. Jones
Article

Abstract

Sch 56592 is a new triazole derivative that possesses potent, broad-spectrum antifungal activity. We evaluated the in vitroactivity of Sch 56592 compared with that of itraconazole, amphotericin B and 5-fluorocytosine against 51 clinical isolates of filamentous fungi, including Aspergillus flavus(10), A. fumigatus(12), Fusariumspp. (13), Rhizopus spp. (6), Pseudallescheria boydii(5), and one isolate each of Acremoniumspp., A. niger, A. terreus, Paecilomycesspp., and Trichodermaspp. In vitrosusceptibility testing was performed using the microdilution broth method outlined in the NCCLS 27-A document. Sch 56592 was highly active against A. flavus(MIC90, 0.25 μg/ml), A. fumigatus(MIC90, 0.12 μg/ml), P. boydii(MIC50, 1 μ/ml) and Rhizopusspp (M1C50, 1 μg/ml). By comparison with itraconazole, Sch 56592 was four- to eight-fold more active against isolates of Aspergillusand both compounds showed equipotent in vitroactivity against P. boydiiand Rhizopusspp. Sch 56592 was four- to 16-fold more active than amphotericin B against Aspergillusspp. and P. boydiiand both antifungal drugs displayed similar activity against Rhizopusspp. Overall, Sch 56592 showed good in vitroactivity against all isolates tested (MIC, ≤ 2 μg/ml) except isolates of Fusarium(MIC range, 1–>4 μg/ml). On the basis of these data Sch 56592 has promising activity against Aspergillus spp. and other species of filamentous fungi that are likely to be encountered clinically. Additional in vitroand in vivostudies are warranted.

Keywords

Itraconazole Invasive Aspergillosis Antimicrob Agent 37th Interscience Rhizopus Arrhizus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • F. Marco
    • 1
  • M.A. Pfaller
    • 1
  • S.A. Messer
    • 1
  • R.N. Jones
    • 1
  1. 1.Medical Microbiology Division. Department of PathologyUniversity of Iowa College of MedicineIowa CityUSA

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