Journal of Neurocytology

, Volume 27, Issue 10, pp 719–730 | Cite as

A light and electron microscopic study of GAT-1-positive cells in the cerebral cortex of man and monkey

  • W.Y. Ong
  • T.T. Yeo
  • V.J. Balcar
  • L.J. Garey



Specimens of human cerebral cortex were obtained during neurosurgical operations and studied by immunocytochemistry and electron microscopy, using antibodies to the GABA transporter GAT-1. Cortical material from macaque monkeys was prepared similarly. Large numbers of GAT-1-positive non-pyramidal neurons were observed in layers I, II, V, and VI of the cortex. Electron microscopy also showed that the GAT-1-positive axon terminals formed symmetrical and not asymmetrical synapses, suggesting that they were the terminals of non-pyramidal neurons. Processes of cells in the walls of blood vessels were also labelled. We conclude that GAT-1 is present in cell bodies and axon terminals of non-pyramidal neurons, and a population of mural cells in blood vessels, in the primate cerebral cortex.


Electron Microscopy Blood Vessel Cerebral Cortex Cell Body Microscopic Study 
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Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • W.Y. Ong
    • 1
  • T.T. Yeo
    • 2
  • V.J. Balcar
    • 3
  • L.J. Garey
    • 4
  1. 1.Department of AnatomyNational University of SingaporeSingapore
  2. 2.Department of NeurosurgeryTan Tock Seng HospitalSingapore
  3. 3.Department of Anatomy and Histology and Sydney Institute for Biomedical ResearchUniversity of SydneyAustralia
  4. 4.Division of Neuroscience, Imperial College School of MedicineCharing Cross HospitalLondonUK

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