Molecular and Cellular Biochemistry

, Volume 174, Issue 1, pp 305–319

Reactive oxygen species, mitochondria, apoptosis and aging

  • S. Papa
  • V.P. Skulachev

DOI: 10.1023/A:1006873518427

Cite this article as:
Papa, S. & Skulachev, V. Mol Cell Biochem (1997) 174: 305. doi:10.1023/A:1006873518427


In this paper, we shall review various antioxygen defense systems of the cell paying particular attention to those that prevent superoxide formation rather than scavenge already formed superoxide and its products. The role of uncoupled, decoupled and non-coupled respiration, mitochondrial pore, mitochondrion-linked apoptosis will be considered. Mitochondrial theory of aging will be regarded in context of reactive oxygen species-induced damage of mitochondrial DNA. (Mol Cell Biochem 174: 305–319, 1997)

mitochondrial metabolism mitochondrial DNA superoxide radicals 

Copyright information

© Kluwer Academic Publishers 1997

Authors and Affiliations

  • S. Papa
    • 1
  • V.P. Skulachev
    • 2
  1. 1.Institute of Medical Biochemistry and ChemistryUniversity of BariBariItaly
  2. 2.A.N. Belozersky Institute of Physico-Chemical BiologyMoscow State UniversityMoscowRussia

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