Molecular and Cellular Biochemistry

, Volume 182, Issue 1–2, pp 135–141

Potential mechanism(s) involved in the regulation of glycogen synthesis by insulin

  • Ashok K. Srivastava
  • Sanjay K. Pandey

DOI: 10.1023/A:1006857527588

Cite this article as:
Srivastava, A.K. & Pandey, S.K. Mol Cell Biochem (1998) 182: 135. doi:10.1023/A:1006857527588


Stimulation of glycogen synthesis is one of the major physiological responses modulated by insulin. Although, details of the precise mechanism by which insulin action on glycogen synthesis is mediated remains uncertain, significant advances have been made to understand several steps in this process. Most importantly, recent studies have focussed on the possible role of glycogen synthase kinase-3 (GSK-3) and glycogen bound protein phosphatase-1 (PP-1G) in the activation of glycogen synthase (GS) - a key enzyme of glycogen metabolism. Evidence is also accumulating to establish a link between insulin receptor induced signaling pathway(s) and glycogen synthesis. This article summarizes the potential contribution of various elements of insulin signaling pathway such as mitogen activated protein kinase (MAPK), protein kinase B (PKB), and phosphatidyl inositol 3-kinase (PI3-K) in the activation of GS and glycogen synthesis.

glycogen synthesis glycogen synthase glycogen synthase kinase-3 protein kinase B protein phosphatase-1 phosphatidyl inositol 3-kinase 

Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • Ashok K. Srivastava
    • 1
  • Sanjay K. Pandey
    • 1
  1. 1.Research Center, CHUM, Hôtel-Dieu Pavilion, Department of MedicineUniversity of MontréalMontréalCanada

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