Molecular and Cellular Biochemistry

, Volume 179, Issue 1–2, pp 159–168 | Cite as

Cytokines in exertion-induced skeletal muscle injury

  • Joseph G. Cannon
  • Barbara A. St. Pierre


Cytokines are a diverse family of intercellular signaling proteins that influence the movement, proliferation, differentiation, metabolism and membrane processes of target cells. Synthesis and release of cytokines from leukocytes in response to microbial stimuli are well known. This review, however, will present evidence that non-infectious stimuli can induce cytokine secretion from leukocytes and other cells (including muscle cells) following myocellular injury. The biological actions and potential adaptive values of these cytokines through the course of muscle necrosis and regeneration will be described.

skeletal muscle cytokines tumour necrosis factor leukocyte fibroblasts neutrophils necrosis regeneration exercise 


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Copyright information

© Kluwer Academic Publishers 1998

Authors and Affiliations

  • Joseph G. Cannon
    • 1
  • Barbara A. St. Pierre
    • 1
  1. 1.Intercollege Physiology Program and Department of KinesiologyPennsylvania State UniversityUSA

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