Origins of life and evolution of the biosphere

, Volume 29, Issue 5, pp 511–520 | Cite as

Prebiotic Formation of ADP and ATP from AMP, Calcium Phosphates and Cyanate in Aqueous Solution

  • Yukio Yamagata


Adenosine-5′-triphosphate was synthesized by the phosphorylation of adenosine-5′-diphosphate in aqueous solution containing cyanate as a condensing reagent and insoluble calcium phosphate produced from phosphate and calcium chloride. In a similar manner, adenosine-5′-diphosphate was synthesized from adenosine-5′-monophosphate. When the experiment was carried out in the conditions of 4 °C and pH 5.75, the formation of adenosine-5′-diphosphate and adenosine-5′-triphosphate from adenosine-5′-monophosphate was observed in the yields of 19 and 7%, respectively. The other nucleoside-5′-triphosphates were also produced from their respective diphosphates.


Calcium Phosphate Chloride Aqueous Solution Organic Chemistry 
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  1. Abelson, P. H.: 1966, Proc. N.A.S. 55, 1365.Google Scholar
  2. Etaix, E. and Orgel, L. E.: 1978, J. Carbohydrates-Nucleosides-Nucleotides 5, 91.Google Scholar
  3. Handschuh, G. J., Lohrmann, R. and Orgel, L. E.: 1973, J. Molec. Evol. 2, 251.PubMedGoogle Scholar
  4. Kasting, J. F. and Ackerman, T. P.: 1987, Science 234, 1383.Google Scholar
  5. Lohrmann, R. and Orgel, L. E.: 1968, Science 161, 64.PubMedGoogle Scholar
  6. Lohrmann, R. and Orgel, L. E.: 1971, Science 171, 490.PubMedGoogle Scholar
  7. Lohrmann, R.: 1975, J. Molec. Evol. 6, 237.PubMedGoogle Scholar
  8. Lohrmann, R.: 1977, J. Molec. Evol. 10, 137.PubMedGoogle Scholar
  9. Miller, S. L. and Parris, M.: 1964, Nature 204, 1248.Google Scholar
  10. Miller, S. L. and Orgel, L. E.: 1974, The Origin of Life on the Earth, (Prentice-Hall, Englewood Cliffs).Google Scholar
  11. Ponnamperuma, C., Sagan, C. and Mariner, R.: 1963, Nature 199, 222.PubMedGoogle Scholar
  12. Ponnamperuma, C. and Mack, R.: 1965, Science 148, 1221.PubMedGoogle Scholar
  13. Rank, D. M. Townes, C. H. and Welch, W. J.: 1971, Science 174, 1083.Google Scholar
  14. Rubey, W. W.: 1955, Geol. Soc. America, Special Paper no. 62, pp. 631–650.Google Scholar
  15. Schwartz, A. and Ponnamperuma, C.: 1968, Nature 218, 443.PubMedGoogle Scholar
  16. Steinman, G., Kenyon, D. H. and Calvin, M.: 1965, Nature 206, 707.Google Scholar
  17. Yamagata, Y., Matsukawa, T., Mohri, T. and Inomata, K.: 1979, Nature 282, 284.PubMedGoogle Scholar
  18. Yamagata, Y., Mohri, T., Yamakoshi, M. and Inomata, K.: 1981, Origins of Life 11, 233.PubMedGoogle Scholar
  19. Yamagata, Y. and Mohri, T.: 1982, Origins of Life 12, 41.PubMedGoogle Scholar
  20. Yamagata, Y., Watanabe, H., Saitoh, M. and Namba, T.: 1991, Nature 352, 516.CrossRefPubMedGoogle Scholar
  21. Yamagata, Y., Inoue, H. and Inomata, K.: 1995, Origins Life Evol. Biosphere 25, 47.Google Scholar

Copyright information

© Kluwer Academic Publishers 1999

Authors and Affiliations

  • Yukio Yamagata
    • 1
  1. 1.Laboratory of Chemical EvolutionShowei-machi, Kanazawa, IshikawaJapan

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