Biology and Philosophy

, Volume 15, Issue 4, pp 509–533 | Cite as

Selfhood, Immunity, and the Biological Imagination: The Thought of Frank Macfarlane Burnet

  • Eileen Crist
  • Alfred I. Tauber
Article

Abstract

The language of self and nonself has had a prominent place inimmunology. This paper examines Frank Macfarlane Burnet's introductionof the language of selfhood into the science. The distinction betweenself and nonself was an integral part of Burnet's biological outlook– of his interest in the living organism in its totality, itsactivities, and interactions. We show the empirical and conceptualwork of the language of selfhood in the science. The relation betweenself and nonself tied into Burnet's ecological vision of host-parasiteinteraction. The idiom of selfhood also enabled Burnet to organizeand unify a diversity of immune phenomena. Rather than approach thelanguage of self and nonself as a bluntly imposed metaphor, we focuson its endogenous origins and immanent uses in immunology.

biological thought-style immunology self and nonself 

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References

  1. Burnet, F. Macfarlane: 1940, Biological Aspects of Infectious Disease, Cambridge University Press, Cambridge.Google Scholar
  2. Burnet, F. Macfarlane: 1944, ‘Some Borderlands of Microbiology, Genetics and Biochemistry’, The Australian Journal of Science 7(1), 1–6.Google Scholar
  3. Burnet, F. Macfarlane: 1946, The Virus as Organism, Cambridge University Press, Cambridge.Google Scholar
  4. Burnet, F. Macfarlane: 1959, The Clonal Selection Theory of Acquired Immunity, Cambridge University Press, Cambridge.Google Scholar
  5. Burnet, F. Macfarlane: 1962, The Integrity of the Body: A Discussion of Modern Immunological Ideas, Harvard University Press, Cambridge.Google Scholar
  6. Burnet, F. Macfarlane: 1967, ‘Impact on Ideas of Immunology’, Cold Spring Harbor Symposium on Quantitative Biology 32, 1–8.Google Scholar
  7. Darwin, C.: 1964 [1859], On the Origin of Species. A Facsimile of the First Edition, Harvard University Press, Cambridge.Google Scholar
  8. Ehrlich, P.: 1956 [1897], ‘The Assay of the Activity of Diphtheria-curative Serum and Its Theoretical Basis’, in F. Himmelweit (ed.), The Collected Papers of Paul Ehrlich, Pergamon Press, London, pp. 107–125.Google Scholar
  9. Fleck, Ludwik: 1979 [1935], Genesis and Development of a Scientific Fact, The University of Chicago Press, Chicago.Google Scholar
  10. Haraway, Donna: 1991, ‘The Biopolitics of Postmodern Bodies: Constitutions of Self in Immune System Discourse’, in Simians, Cyborgs, and Women: The Reinvention of Nature, Routledge, New York.Google Scholar
  11. Janeway C.A. and Travers, P.: 1994, Immunobiology, London Current Biology Ltd./Garland Publishing Inc.Google Scholar
  12. Levins, R and Lewontin, Richard: 1985, The Dialectical Biologist, Harvard University Press, Cambridge.Google Scholar
  13. Lewontin, Richard: 1991, Foreword to Organism and the Origins of Self, A.I. Tauber (ed.), Kluwer Academic Publishers, Dordrecht.Google Scholar
  14. Lowy, Ilana: 1991, ‘The Immunological Construction of the Self’, in A.I. Tauber (ed.), Organism and the Origins of Self, Kluwer Academic Publishers, Dordrecht.Google Scholar
  15. Lowy, Ilana: 1992, ‘The Strength of Loose Concepts – Boundary Concepts, Federative Experimental Strategies and Disciplinary Growth: The Case of Immunology’, History of Science XXX, 371–396.Google Scholar
  16. Martin, Emily: 1990, “Toward an Anthropology of Immunology: The Body as Nation State”, Medical Anthropology Quarterly 4, 410–426.Google Scholar
  17. Mazumdar, Pauline M.H.: 1995, Species and Specificity.An Interpretation of the History of Immunology, Cambridge University Press, Cambridge.Google Scholar
  18. Metchnikoff, Elie: 1968 [1892], Lectures on the Comparative Pathology of Inflammation, Dover Publications, Inc., New York.Google Scholar
  19. Metchnikoff, Elie: 1968 [1905], Immunity in Infective Diseases, Johnson Reprint Corporation, New York.Google Scholar
  20. Podolsky, Scott H. and Tauber, Alfred I.: 1997, The Generation of Diversity: Clonal Selection Theory and the Rise of Molecular Immunology, Harvard University Press, Cambridge.Google Scholar
  21. Silverstein, Arthur M.: 1989, A History of Immunology, Academic Press, Inc., San Diego.Google Scholar
  22. Tauber, Alfred I.: 1991, ‘Speculations Concerning the Origins of Self’, in Organism and the Origins of Self, Kluwer Academic Publishers, Dordrecht.Google Scholar
  23. Tauber, Alfred I. (ed.): 1991, Organism and the Origins of Self, Kluwer Academic Publishers, Dordrecht.Google Scholar
  24. Tauber, Alfred I.: 1994, The Immune Self: Theory or Metaphor? Cambridge University Press, Cambridge.Google Scholar
  25. Tauber, Alfred I.: 1995, ‘Postmodernism and Immune Selfhood’, Science in Context 8(4), 579–607.Google Scholar
  26. Tauber, Alfred I. and Podolsky, Scott H.: 1994, ‘Frank Macfarlane Burnet and the Immune Self’, Journal of the History of Biology 27, 531–573.Google Scholar
  27. Tauber, Alfred I. and Chernyak, L.: 1991, Metchnikoff and the Origins of Immunology.From Metaphor to Theory, Oxford University Press, Oxford.Google Scholar

Copyright information

© Kluwer Academic Publishers 2000

Authors and Affiliations

  • Eileen Crist
    • 1
  • Alfred I. Tauber
    • 2
  1. 1.Center for Interdisciplinary StudiesVirginia TechBlacksburgU.S.A.
  2. 2.Center for Philosophy and History of ScienceBoston UniversityBostonU.S.A.

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